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Picture of (6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one

(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one

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Origin: China

Cas No: 125-58-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 125-58-6 Formula: C21H27NO Molecular Weight: 309.44500

    Description

    Levomethadone (INN; L-Polamidon, L-Polamivet, Levadone, Levothyl), or levamethadone, is a synthetic opioid analgesic and antitussive which is marketed in Europe and is used for pain management and in opioid maintenance therapy. In addition to being used as a pharmaceutical drug itself, levomethadone, or R-(−)-methadone, is the active enantiomer of methadone, having approximately 50x the potency of the S-(+)-enantiomer as well as greater μ-opioid receptor selectivity. Accordingly, it is about twice as potent as methadone by weight and its effects are virtually identical in comparison. In addition to its activity at the opioid receptors, levomethadone has been found to act as a weak competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor complex and as a potent noncompetitive antagonist of the α3β4 nicotinic acetylcholine (nACh) receptor.
    There is now an asymmetric synthesis available to prepare both levomethadone [R-(−)-methadone] and dextromethadone [S-(+)-methadone].
    The separation of the stereoisomers is one of the easier in organic chemistry and is described in the original patent. It involves "treatment of racemic methadone base with d-(+)-tartaric acid in an acetone/water mixture [which] precipitates almost solely the dextro-methadone levo-tartrate, and the more potent levo-methadone can easily be retrieved from the mother liquor in a high state of optical purity"

    Basic Info

    Chemical Name (6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one
    Synonyms

    l-Polamivet;
    L-Polamidon;
    Levothyl;
    l-methadone;
    3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-;
    Levomethadone;
    Levadone;
    Polamivet;

    CAS No. 125-58-6
    Molecular Formula C21H27NO
    Molecular Weight 309.44500
    PSA 20.31000
    LogP 4.29200

    Properties

    Density 1.009g/cm3
    Boiling Point 423.7ºC at 760mmHg
    Melting Point 99-100ºC
    Flash Point 126.5ºC
    Refractive Index 1.538
    Vapor Pressure 2.2E-07mmHg at 25°C

    Safety Info

    HS Code 2922399090

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