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9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one

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Origem: China

Cas No: 99614-02-5

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Property

    CAS No.: 99614-02-5 Formula: C18H19N3O Molecular Weight: 293.36300

    Description

    Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also useful in gastroenteritis. It has little effect on vomiting caused by motion sickness. It can be given by mouth, by injection into a muscle or into a vein.
    Common side effects include diarrhea, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic receptors.
    Ondansetron was first used medically in 1990. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost of the injectable form in the developing world is about 0.10 to 0.76 USD per dose. In the United States it costs about 1.37 USD per tablet.

    Basic Info

    Chemical Name 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
    Synonyms

    ONDANSETRON HYDROCHLORIDE DIHYDRATE;
    9-METHYL-3-[(2-METHYL-1H-IMIDAZOLYL)METHYL]-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE;
    ONDANSETRON-D5;
    ONDANSETRON HCL D6;
    9-METHYL-3-(2-METHYL-1H-IMIDAZOLYL)-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE;
    ONDANSETRONBASE;
    R(+)-Ondansetron;
    Ondansetro;
    ONDANSETRON HYDROCHLORIDE;
    9-METHYL-3-[(2-METHYL-1H-IMIDAZOLYL)-METHYL]-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE;
    ONDANESTRON;
    ONDANSETRON FOR LC SYSTEM SUITABILITY, EP STANDARD;
    Ondansetron;
    ONDANSETRON HCL;

    CAS No. 99614-02-5
    Molecular Formula C18H19N3O
    Molecular Weight 293.36300
    PSA 39.82000
    LogP 3.12850

    Properties

    Appearance & Physical State White to yellow crystals
    Density 1.27 g/cm3
    Boiling Point 546ºC at 760 mmHg
    Melting Point 231 - 232ºC
    Flash Point 284ºC
    Refractive Index 1.691
    Storage Condition -20ºC

    Safety Info

    RTECS FE6375500
    Safety Statements S45
    HS Code 2933990090
    WGK Germany 3
    RIDADR UN 2811 6.1/PG 3
    Risk Statements R25
    Hazard Codes T; Xi

    Synthesis Route

    ONDANSETRON HYDROCHLORIDE9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
    N-(trimethylsilyl)-2-methylimidazole+9-Methyl-3-methylene-2,3-dihydro-1H-carbazol-4(9H)-one9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
    2-Methylimidazole+1,2,3,4-Tetrahydro-9-methylcarbazol-4-one9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one

    Precursor

    1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
    ONDANSETRON HYDROCHLORIDE
    9-Methyl-3-methylene-2,3-dihydro-1H-carbazol-4(9H)-one
    N-(trimethylsilyl)-2-methylimidazole

    Downstream Product

    ONDANSETRON HYDROCHLORIDE

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