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9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one

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начало: Китай

Кас Но: 99614-02-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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CAS No.: 99614-02-5 Formula: C18H19N3O Molecular Weight: 293.36300

Description

Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also useful in gastroenteritis. It has little effect on vomiting caused by motion sickness. It can be given by mouth, by injection into a muscle or into a vein.
Common side effects include diarrhea, headache, sleepiness, and itchiness. Serious side effects include QT prolongation and severe allergic reaction. It appears to be safe during pregnancy but has not been well studied in this group. It is a serotonin 5-HT3 receptor antagonist. It does not have any effect on dopamine receptors or muscarinic receptors.
Ondansetron was first used medically in 1990. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost of the injectable form in the developing world is about 0.10 to 0.76 USD per dose. In the United States it costs about 1.37 USD per tablet.

Basic Info

Chemical Name	9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
Synonyms	ONDANSETRON HYDROCHLORIDE DIHYDRATE; 9-METHYL-3-[(2-METHYL-1H-IMIDAZOLYL)METHYL]-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE; ONDANSETRON-D5; ONDANSETRON HCL D6; 9-METHYL-3-(2-METHYL-1H-IMIDAZOLYL)-METHYL-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE; ONDANSETRONBASE; R(+)-Ondansetron; Ondansetro; ONDANSETRON HYDROCHLORIDE; 9-METHYL-3-[(2-METHYL-1H-IMIDAZOLYL)-METHYL]-1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE; ONDANESTRON; ONDANSETRON FOR LC SYSTEM SUITABILITY, EP STANDARD; Ondansetron; ONDANSETRON HCL;
CAS No.	99614-02-5
Molecular Formula	C18H19N3O
Molecular Weight	293.36300
PSA	39.82000
LogP	3.12850

Properties

Appearance & Physical State	White to yellow crystals
Density	1.27 g/cm3
Boiling Point	546ºC at 760 mmHg
Melting Point	231 - 232ºC
Flash Point	284ºC
Refractive Index	1.691
Storage Condition	-20ºC

Safety Info

RTECS	FE6375500
Safety Statements	S45
HS Code	2933990090
WGK Germany	3
RIDADR	UN 2811 6.1/PG 3
Risk Statements	R25
Hazard Codes	T; Xi

Synthesis Route

ONDANSETRON HYDROCHLORIDE→9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
N-(trimethylsilyl)-2-methylimidazole+9-Methyl-3-methylene-2,3-dihydro-1H-carbazol-4(9H)-one→9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one
2-Methylimidazole+1,2,3,4-Tetrahydro-9-methylcarbazol-4-one→9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4(9H)-one

Precursor

1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
ONDANSETRON HYDROCHLORIDE
9-Methyl-3-methylene-2,3-dihydro-1H-carbazol-4(9H)-one
N-(trimethylsilyl)-2-methylimidazole

Downstream Product

ONDANSETRON HYDROCHLORIDE

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