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phenacetin

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Origin: China

Cas No: 62-44-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    62-44-2
    Other Names:
    Phenacetin
    MF:
    C10H13NO2
    EINECS No.:
    200-533-0
    Place of Origin:
    Shaanxi, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99%
    Brand Name:
    JXY
    Model Number:
    JXY - P
    Application:
    Cosmetic Raw Materials
    Appearance:
    White powder, White Powder
    Product Name:
    Phenacetin
    Certificate:
    ISO9001
    Shelf life:
    2 Years
    Sample:
    Available
    COA:
    Available
    MOQ:
    100 gram
    Storage:
    Cool Dried Storage
    Package:
    1kg/bag 25kg/drum
    Assay:
    Min 99%

    Packaging&Delivery

    Packaging Details
    1kg/foil bag,25 kg/drum
    Port
    china port
    Lead Time:
    Quantity(Kilograms)1 - 100101 - 500501 - 1000>1000
    Est. Time(days)456To be negotiated

    Products Description

    CAS No.
    62-44-2
    Other Names
    Phenacetin
    MF
    C10H13NO2
    EINECS No.
    200-533-0
    Place of Origin
    China
    Purity
    99%
    Appearance
    White powder
    Usage
    Cosmetic Raw Materials
    density
    1.099g/cm3

  • Property

    CAS No.: 62-44-2 Formula: C10H13NO2 Molecular Weight: 179.21600

    Description

    Phenacetin (or acetophenetidin) is a pain-relieving and fever-reducing drug, which was widely used between its introduction in 1887 and the 1983 ban imposed by the FDA on its use in the United States. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.

    Basic Info

    Chemical Name phenacetin
    Synonyms

    Achrocidin;
    Acetphenetidin;
    Contradouleur;
    p-Acetophenetidide;
    Codempiral;
    p-ethoxyacetanilide;
    Acetophenetin;
    N-(4-ethoxyphenyl)acetamide;
    Phenacetin;
    Acetophenetidin;
    Acetamide, N-(4-ethoxyphenyl)-;
    4'-ethoxyacetanilide;
    Acetophenetidine;

    CAS No. 62-44-2
    Molecular Formula C10H13NO2
    Molecular Weight 179.21600
    PSA 38.33000
    LogP 2.11670

    Properties

    Appearance & Physical State white crystalline powder
    Density 1.099 g/cm3
    Boiling Point 132 °C / 4mmHg
    Melting Point 133-138ºC
    Refractive Index 1.505 (20ºC)
    Water Solubility 0.076 g/100 mL
    Stability Stable. Incompatible with strong oxidizing agents, strong acids.
    Storage Condition 2-8ºC

    Safety Info

    RTECS AM4375000
    Safety Statements S45-S53
    HS Code 2924291000
    WGK Germany 3
    Risk Statements R22; R45
    Hazard Codes T

    Synthesis Route

    nimesulide→propylparaben+phenacetin
    (N-acetyl-4-ethoxyanilino) 2,2-dimethylpropanoate→phenacetin+Paracetamol
    (4-ethoxyphenyl)urea+sodium acetate→acetamide+phenacetin

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Capillary BP-1 200. 1660. isothermal
    Capillary BP-1 200. 1666. isothermal
    Packed SE-30 180. 1695. isothermal
    Capillary SPB-1 250. 1699. isothermal
    Packed OV-1 200. 1680. isothermal

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Unreported LDLo - Lowest published lethal dose Human - man 74 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 3600 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 634 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    1-Ethoxy-4-nitrobenzene
    Acetic anhydride
    Triacetin
    4'-Ethoxyacetophenone

    Downstream Product

    6-ethoxyquinoline
    1-(5-Amino-2-hydroxyphenyl)ethanone
    quinolin-6-ol
    6-ethoxy-2-methyl-1,3-benzothiazole

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