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Progesterone Acetate

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Origin: China

Cas No: 302-23-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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Products Specification
Product Description

Quick Details
CAS No.:
302-23-8
Other Names:
17a-acetoxyprogesterone
MF:
C23H32O4
Place of Origin:
Anhui, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Packaging&Delivery
Packaging Details
25kg/drum
Port
Shanghai

Property

CAS No.: 302-23-8 Formula: C23H32O4 Molecular Weight: 372.49800

Description

Hydroxyprogesterone acetate (HPA) (INN) (brand name Prodox), or 17α-hydroxyprogesterone acetate (17-OHPA), also known as acetoxyprogesterone, is a synthetic, steroidal, orally-active progestin which was discovered by Upjohn in the 1950s and, in 1960, was marketed for use in veterinary medicine. It is a derivative of progesterone and the acetate ester of 17-hydroxyprogesterone, and is a parent compound of a number of progestins, including chlormadinone acetate, cyproterone acetate, medroxyprogesterone acetate, and megestrol acetate.
Hydroxyprogesterone acetate is of relatively low potency as a progestogen, which may explain its limited relative use. It is 100-fold less potent than medroxyprogesterone acetate, 400-fold less potent than chlormadinone acetate, and 1200-fold less potent than cyproterone acetate.

Basic Info

Chemical Name	Progesterone Acetate
Synonyms	17α-Acetoxyprogesterone; 17a-Hydroxy-progesterone acetate; 17ALPHA-ACETOXYPROGESTERONE; 17α-Hydroxy-4-pregnene-3,20-dione 17-acetate; Chlormadinone acetate impurity G; ProgesteroneAcetate; 4-Pregnen-17α-ol-3,20-dione acetate; Hydroxyprogesterone acetate;
CAS No.	302-23-8
Molecular Formula	C23H32O4
Molecular Weight	372.49800
PSA	60.44000
LogP	4.26510

Properties

Appearance & Physical State	white powder
Density	1.14 g/cm3
Boiling Point	490.2ºC at 760 mmHg
Melting Point	249-250ºC
Flash Point	211.6ºC
Refractive Index	1.542

Safety Info

RTECS	TU5074000
Safety Statements	S22; S24/25; S45
WGK Germany	3
RIDADR	UN 2811 6
Risk Statements	R40
Hazard Codes	Xn

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Rodent - rat	72 mg/kg,male 9 day(s) pre-mating	1.Reproductive-Paternal Effects-prostate, seminal vesicle, Cowper's gland, accessory glands
Subcutaneous	TDLo - Lowest published toxic dose	Rodent - mouse	1 mg/kg,female 1 day(s) pre-mating	1.Reproductive-Maternal Effects-uterus, cervix, vagina
Oral	TDLo - Lowest published toxic dose	Mammal - dog	896 mg/kg,female 32 week(s) pre-mating	1.Reproductive-Maternal Effects-menstrual cycle changes or disorders

Downstream Product

17-acetoxy-6α-nitro-pregn-4-ene-3,20-dione
17-α hydroxy-4-bromo-4-pregnene-3,20-dione
17α-benzoyloxy-4,6-pregnadiene-3,20-dione
3β,17α-Dihydroxypregna-4,6-dien-20-one 17-acetate

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