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Tetrodotoxin

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Origin: China

Cas No: 4368-28-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 4368-28-9 Formula: C11H17N3O8 Molecular Weight: 319.26800

Description

Tetrodotoxin is a highly selective, reversible sodium channel blocker.

Basic Info

Chemical Name	Tetrodotoxin
Synonyms	Spheroidine; (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-(1,3)dioxocino(6,5-d)pyrimidine-4,7,10,11,12-pentol; Fugu poison,Maculotoxin,TTX; Fugu Toxin; Tetradotoxin; tetrdotoxin;
CAS No.	4368-28-9
Molecular Formula	C11H17N3O8
Molecular Weight	319.26800
PSA	192.32000
LogP	-6.03400

Properties

Appearance & Physical State	white to beige solid.
Density	2.78 g/cm3
Boiling Point	702.6ºC at 760 mmHg
Melting Point	225ºC dec
Flash Point	378.7ºC
Refractive Index	2.087
Storage Condition	2-8ºC

Safety Info

RTECS	IO1450000
Hazard Class	6.1(a)
Safety Statements	22-36/37/39-45
Packing Group	I
WGK Germany	3
RIDADR	UN 3462 6
Risk Statements	R26/27/28
Hazard Codes	T+

Synthesis Route

(E)-2-((2R,5S,6R)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxycyclohex-3-en-1-ylidene)acetaldehyde→Tetrodotoxin
(1S,4R,6R,E)-4-((benzyloxy)methoxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-(2-hydroxyethylidene)cyclohex-2-en-1-ol→Tetrodotoxin
methyl (E)-2-((2R,5S,6R)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxycyclohex-3-en-1-ylidene)acetate→Tetrodotoxin

Precursor

methyl (E)-2-((2R,5S,6R)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxycyclohex-3-en-1-ylidene)acetate
(1S,3S,5R,8S,8aR)-1-(((tert-butyldimethylsilyl)oxy)methyl)-7-(((tert-butyldiphenylsilyl)oxy)methyl)-5-hydroxy-3-methoxy-3,5,8,8a-tetrahydro-1H-isochromen-8-yl benzoate
(E)-2-((2R,5S,6R)-2-((benzyloxy)methoxy)-4-(((tert-butyldiphenylsilyl)oxy)methyl)-6-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-5-hydroxycyclohex-3-en-1-ylidene)acetaldehyde
((1S,2R,3S,4R,5S,6R)-2-acetoxy-5-((benzyloxy)methoxy)-4-((tert-butoxycarbonyl)amino)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-(2-oxoethyl)-7-oxabicyclo[4.1.0]heptan-1-yl)methyl benzoate

Downstream Product

73600-89-2
Tetrodonic acid

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