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medroxyprogesterone acetate

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Origin: China

Cas No: 71-58-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
71-58-9
Other Names:
Medroxyprogesterone acetate
MF:
C24H34O4
EINECS No.:
C24H34O4
Place of Origin:
China
Type:
Others
Purity:
995
Brand Name:
Hanways
Model Number:
Top
Product name:
Medroxyprogesterone acetate
Density:
1.1±0.1 g/cm3
Boiling Point:
496.4±45.0 °C at 760 mmHg
CAS:
71-58-9
Grade:
Phamaceutical Grade
Storage:
Cool Dry Place
Sample:
Availiable
Molecular Weight:
386.58
EINECS:
200-757-9
Molecular formula:
C24H34O4
Packaging&Delivery
Packaging Details
100g/bag, 1kg/bag, 25kg/drum or as customer required
Port
Shanghai, Shenzhen or Beijing
Lead Time:
Quantity(Grams) 1 - 3000 >3000
Est. Time(days) 3 To be negotiated

Property

CAS No.: 71-58-9 Formula: C24H34O4 Molecular Weight: 386.52400

Description

Progestogen; an injectable contraceptive.

Basic Info

Chemical Name	medroxyprogesterone acetate
Synonyms	Medroxiprogesteron Acetate; Medroxyprogesterone 17-acetate;
CAS No.	71-58-9
Molecular Formula	C24H34O4
Molecular Weight	386.52400
PSA	60.44000
LogP	4.51270

Properties

Appearance & Physical State	white powder
Density	1.13 g/cm3
Boiling Point	496.4ºC at 760 mmHg
Melting Point	206-207ºC
Flash Point	213.2ºC
Refractive Index	1.536
Stability	Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents.
Storage Condition	Refrigerator

Safety Info

RTECS	TU5010000
Safety Statements	S22-S36/37/39-S45
WGK Germany	3
Risk Statements	R40; R48
Hazard Codes	Xn

Synthesis Route

[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-6-methylidene-3-oxo-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate→medroxyprogesterone acetate
(8R,9S,10R,13S,14S,17R)-17-Acetyl-6,10,13-trimethyl-1,2,4,7,8,9,1 0,11,12,13,14,15,16,17-tetradecahydrospiro[cyclopenta[a]phenanthr ene-3,2'-[1,3]dioxolan]-17-yl acetate→medroxyprogesterone acetate
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione→medroxyprogesterone acetate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intravenous	TDLo - Lowest published toxic dose	Human - woman	10 mg/kg	1.Sense Organs and Special Senses (Eye)-increased intraocular pressure
Intravenous	TDLo - Lowest published toxic dose	Human - woman	21 mg/kg	1.Sense Organs and Special Senses (Eye)-increased intraocular pressure
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>6400 mg/kg	1.Liver-other changes

Precursor

17α-Hydroxypregn-5-ene-3,20-dione-3,20-bis(ethyleneketal)
6β-Methyl-3,20-bis-ethylendioxy-pregnandiol-(5α,17α)-11-on
5,17-dihydroxy-6β-methyl-5α-pregnane-3,20-dione
[(8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-6-methylidene-3-oxo-1,2,7,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate

Downstream Product

megestrol acetate
megestrol
medroxyprogesterone
[(5S,6S,8R,9S,10S,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

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