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3α-hydroxy-5β-pregnan-20-one

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Origin: China

Cas No: 128-20-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 128-20-1 Formula: C21H34O2 Molecular Weight: 318.49300

Description

Pregnanolone (3α-hydroxy-5β-pregnan-20-one or 3α,5β-tetrahydroprogesterone; sometimes abbreviated as 3α,5β-THP), also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone. It is a positive allosteric modulator of the GABAA receptor, as well as a negative allosteric modulator of the glycine receptor, and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects. It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for that reason was never marketed.

Basic Info

Chemical Name	3α-hydroxy-5β-pregnan-20-one
Synonyms	5-Pregnan-3-ol-20-one; Pregnanolone II; Butabindide oxalate; 3alpha-hydroxy-5beta-pregnan-20-one; Pregnan-20-one,3-hydroxy-, (3a,5b)-; Pregnan-20-one, 3-hydroxy-, (3α,5β)-; pregnanalone; PREGNAN-3A-OL-20-ONE;
CAS No.	128-20-1
Molecular Formula	C21H34O2
Molecular Weight	318.49300
PSA	37.30000
LogP	4.59520

Properties

Appearance & Physical State	Solid.
Density	1.05 g/cm3 (20ºC)
Boiling Point	431.2ºC at 760 mmHg
Melting Point	149ºC
Refractive Index	1.524
Stability	Stable at normal temperatures and pressures.
Storage Condition	Keep tightly closed. Store in a cool dry place.
Vapor Pressure	3.05E-09mmHg at 25°C

Safety Info

Safety Statements	S22; S36
Risk Statements	R40
Hazard Codes	Xn
Hazard Declaration	H351
Signal Word	Warning
Caution Statement	P281
Symbol	GHS08

Synthesis Route

(-)-7β-hydroxy-2,4bβ-dimethyl-1-(pent-3-ynyl)-1,2,3,4,4aα,5,6,7,8,8a,9,10,10aβ-tetradecahydro-2-phenanthrol→3β-hydroxy-5α-pregnan-20-one+3α-hydroxy-5β-pregnan-20-one
Progesterone→5β-pregnane-3,20-dione+3β-hydroxy-5β-pregnan-20-one
5β-pregnane-3,20-dione→3β-hydroxy-5β-pregnan-20-one+3α-hydroxy-5β-pregnan-20-one

GC Analysis