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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Brain and nervous system> 1,5-dimethyl-2-phenylpyrazol-3-one,2,2,2-trichloroethane-1,1-diol
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1,5-dimethyl-2-phenylpyrazol-3-one,2,2,2-trichloroethane-1,1-diol

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Origin: China

Cas No: 480-30-8

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 480-30-8 Formula: C15H18Cl6N2O5 Molecular Weight: 519.03200

    Description

    Dichloralphenazone is a 1:2 mixture of antipyrine with chloral hydrate. In combination with paracetamol and isometheptene, it is the active ingredient of medications for migraine and vascular (tension) headaches, including Epidrin and Midrin. Performance impairments are common with this drug and caution is advised, for example when driving motor vehicles. Additional uses of dichloralphenazone include sedation for the treatment of short-term insomnia, although there are probably better drug choices for the treatment of insomnia.

    Basic Info

    Chemical Name 1,5-dimethyl-2-phenylpyrazol-3-one,2,2,2-trichloroethane-1,1-diol
    Synonyms

    Dichloralantipyrine;
    Dormuphar;
    Sedor;
    dichloralphenazone;
    Ibiodorm;
    Dichloralantipyrin;
    Kloralfenazon;
    Sominat;
    Welldorm;

    CAS No. 480-30-8
    Molecular Formula C15H18Cl6N2O5
    Molecular Weight 519.03200
    PSA 107.85000
    LogP 2.81900

    Properties

    Boiling Point 319ºC at 760 mmHg
    Vapor Pressure 0.000348mmHg at 25°C

    Synthesis Route

    antipyrine+trichloroacetaldehyde→1,5-dimethyl-2-phenylpyrazol-3-one,2,2,2-trichloroethane-1,1-diol

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 1338 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 1437 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 982 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    antipyrine
    trichloroacetaldehyde

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