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(25R)-cholest-5-ene-3β,26-diol

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Origem: China

Cas No: 20380-11-4

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Especificação de produtos
  • Descrição do produto
  • Property

    CAS No.: 20380-11-4 Formula: C27H46O2 Molecular Weight: 402.65300

    Description

    27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). It is a metabolite of cholesterol that is produced by the enzyme CYP27A1.
    A link between high cholesterol and breast cancer has been identified, and it has been proposed that this is due to 27-HC production by CYP27A1. Because of its estrogenic action, 27-HC stimulates the growth of ER-positive breast cancer cells, and has been implicated in limiting the effectiveness of aromatase inhibitors in the treatment of breast cancer. As such, identified CYP27A1 inhibitors, including the marketed drugs anastrozole, fadrozole, bicalutamide, dexmedetomidine, ravuconazole, and posaconazole, have been proposed as potential adjuvant therapies in ER-positive breast cancer.

    Basic Info

    Chemical Name (25R)-cholest-5-ene-3β,26-diol
    Synonyms

    (25R)-cholest-5-ene-3beta,26-diol;
    5,25R-Cholesten-3beta,26-diol;

    CAS No. 20380-11-4
    Molecular Formula C27H46O2
    Molecular Weight 402.65300
    PSA 40.46000
    LogP 6.36110

    Properties

    Density 1.03
    Boiling Point 517.1ºC at 760 mmHg
    Melting Point 172 - 173 °C
    Flash Point 215.6ºC
    Refractive Index 1.537
    Vapor Pressure 7.43E-13mmHg at 25°C

    Synthesis Route

    (20R)-20-(2-hydroxyethyl)-5-pregnen-3β-ol tetrahydropyranyl ether(25R)-cholest-5-ene-3β,26-diol
    (25R)-cholest-5-ene-3β,26-diol
    (25R)-cholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether(25R)-cholest-5-ene-3β,26-diol

    Precursor

    (25R)-cholest-5-en-3β,26-diol 26-(2'-tetrahydropyranyl) ether
    (25R)-cholest-5-ene-3β,16β,26-triol 3β,26-dipivalate
    (20R)-20-(2-hydroxyethyl)-5-pregnen-3β-ol tetrahydropyranyl ether
    (3S,8S,9S,10R,13R,14S,17R)-17-((2R)-7-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

    Downstream Product

    (25R)-5α-cholestane-3β,26-diol 26-pivalate
    (25R)-5α-cholest-14-ene-3α,26-diol 3α,26-diacetate
    (25R)-3-oxo-5α-cholestan-26-oic acid
    (25R)-26-chloro-4,4-dimethyl-5α-cholesta-8,14-dien-3β-ol

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