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3-naphthalen-1-yloxypropane-1,2-diol

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Origin: China

Cas No: 36112-95-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 36112-95-5 Formula: C13H14O3 Molecular Weight: 218.24800

Description

3-(1-Naphthalenyloxy)-1,2-propanediol is an impurity of Propranolol, an β−Adrenergic blocker used as a antihypertensive and antilanginal agent.

Basic Info

Chemical Name	3-naphthalen-1-yloxypropane-1,2-diol
Synonyms	3-(naphthalen-1-yloxy)propane-1,2-diol; rac-3-(1-naphthyloxy)propane-1,2-diol; Propanolol glycol; 3-[1]naphthyloxy-propane-1,2-diol; 1,2-PROPANEDIOL,3-(1-NAPHTHYLOXY); Naphthalene,1-(2,3-dihydroxypropoxy); GNF-Pf-4919; Propranolol glycol; 3-[1]Naphthyloxy-propan-1,2-diol; 1-(2,3-Dihydroxypropoxy)naphthalene;
CAS No.	36112-95-5
Molecular Formula	C13H14O3
Molecular Weight	218.24800
PSA	49.69000
LogP	1.57180

Properties

Density	1.24g/cm3
Boiling Point	437.7ºC at 760 mmHg
Flash Point	218.5ºC
Refractive Index	1.635

Safety Info

HS Code	2909499000
Caution Statement	P280; P312
Symbol	GHS06
Signal Word	Danger
Hazard Declaration	H311

Synthesis Route

α-Naphthyl Glycidyl Ether→3-naphthalen-1-yloxypropane-1,2-diol
1-prop-2-enoxynaphthalene→3-naphthalen-1-yloxypropane-1,2-diol
1-naphthol+3-chloropropane-1,2-diol→3-naphthalen-1-yloxypropane-1,2-diol

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	6900 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	828 mg/kg	1.Peripheral Nerve and Sensation-flaccid paralysis without anesthesia (usually neuromuscular blockage) 2.Behavioral-muscle weakness 3.Lungs, Thorax, or Respiration-other changes
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	88 mg/kg	1.Lungs, Thorax, or Respiration-other changes