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TRANS-4-HYDROXY-D-PROLINE

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Origin: China

Cas No: 3398-22-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 3398-22-9 Formula: C5H9NO3 Molecular Weight: 131.13000

Basic Info

Chemical Name	TRANS-4-HYDROXY-D-PROLINE
Synonyms	D-trans-Hydroxyproli; H-D-HYP-OH; Trans-4-Hydroxy-D-Proline; D-Proline, 4-hydroxy-, trans-; TRANS-D-HYDROXYPROLINE; trans-4-D-Hydroxyproline; trans-D-Hyp; (2R,4S)-4-Hydroxypyrrolidine-2-Carboxylic Acid; D-HYDROXYPYROLINE; D-HYDROXYPROLINE; TRANS-D-4-HYDROXYPROLINE; Trans-4-hydroxy-L-proline;
CAS No.	3398-22-9
Molecular Formula	C5H9NO3
Molecular Weight	131.13000
PSA	69.56000
LogP	-0.87740

Properties

Appearance & Physical State	White crystal or crystalline powder
Density	1.395 g/cm3
Boiling Point	355.2ºC at 760 mmHg
Melting Point	260ºC
Flash Point	168.6ºC
Refractive Index	1.54

Safety Info

Safety Statements	S24/25
HS Code	2933990090
Risk Statements	R22
Hazard Codes	Xn

Synthesis Route

(2R,4R)-1-acetyl-4-(4-methylphenyl)sulfonyloxypyrrolidine-2-carboxylic acid→TRANS-4-HYDROXY-D-PROLINE
N-Acetyl-allo-4-(p-toluenesulfonyloxy)-D-proline Methyl Ester→TRANS-4-HYDROXY-D-PROLINE
N-(3,5-dinitrobenzoyl)-(4R)-hydroxy-L-proline→TRANS-4-HYDROXY-D-PROLINE

Precursor

N-(3,5-dinitrobenzoyl)-(4R)-hydroxy-L-proline
trans-4-hydroxy-D,L-proline
(2R,4R)-1-acetyl-4-(4-methylphenyl)sulfonyloxypyrrolidine-2-carboxylic acid
trans-1-(3,5-dinitro-benzoyl)-4-hydroxy-D-proline

Downstream Product

(2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride
(2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
D-Proline, 4-hydroxy-, methyl ester, (4S)
(2R,4S)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid

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