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TRANS-3-HYDROXY-L-PROLINE

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Origin: China

Cas No: 4298-08-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 4298-08-2 Formula: C5H9NO3 Molecular Weight: 131.13000

Description

trans-3-Hydroxyproline, is a versatile building block, used in the synthesis of various pharmaceutical and biologically active compounds. It is used as an intermediate in the synthesis of ferrocene-hydroxyproline amino acid conjugates.

Basic Info

Chemical Name	TRANS-3-HYDROXY-L-PROLINE
Synonyms	3-(R)-hydroxy-2-(S)-proline; trans-3-hydroxy-(S)-proline; trans-3-Hydroxy-prolin; (2S,3S)-3-hydroxyproline; L-3-HYDROXYPROLINE; 3(S)-trans-hydroxy-L-proline; H-3-HYP-OH; TRANS-3-HYDROXY-L-PR; L-3-TRANS-HYDROXYPROLINE; trans-3-Hydroxy-L-proline; L-trans-3-hydroxyproline; trans-3-Hydroxyproline; (2S,3S)-3-Hydroxypyrrolidine-2-carboxylic acid; H-HYP(3)-OH; H-PRO(3-HYDROXY)-OH; (3S)-3-Hydroxy-L-proline; 3-Hydroxy-L-proline;
CAS No.	4298-08-2
Molecular Formula	C5H9NO3
Molecular Weight	131.13000
PSA	69.56000
LogP	-0.87740

Properties

Appearance & Physical State	White to light beige powder
Density	1.395g/cm3
Boiling Point	355.2ºC at 760mmHg
Melting Point	235ºC
Flash Point	168.6ºC
Refractive Index	1.54

Safety Info

Safety Statements	S22-S24/25
HS Code	2933990090

Synthesis Route

(2S,3S)-N-benzyl-2-hydroxyproline→TRANS-3-HYDROXY-L-PROLINE
potassium (2S,3S)-2-amino-3-hydroxy-5,5-dimethoxypentanoate→TRANS-3-HYDROXY-L-PROLINE
L-proline→TRANS-3-HYDROXY-L-PROLINE

Precursor

L-proline
potassium (2S,3S)-2-amino-3-hydroxy-5,5-dimethoxypentanoate
methyl (2S,3S)-3-hydroxy-2-[(9-phenyl-9-fluorenyl)-amino]-4-pentenoate
(2S,3S)-N-benzyl-2-hydroxyproline

Downstream Product

1-O-tert-butyl 2-O-methyl (2S,3S)-3-hydroxypyrrolidine-1,2-dicarboxylate
(2S,3S)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Fmoc-(2S,3S)-3-hydroxypyrrolidine-2-carboxylic acid

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