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5-oxo-D-proline

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Origin: China

Cas No: 4042-36-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

Quick Details
CAS No.:
4042-36-8
Other Names:
5-Oxo-D-proline
MF:
C5H7NO3
EINECS No.:
223-735-0
Place of Origin:
Shandong, China
Type:
Anesthetic Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
BOSS
Model Number:
4042-36-8
Purity:
99%min
Product name:
D-Pyroglutamic acid
Description:
powder
CAS:
4042-36-8
Synonyms:
5-Oxo-D-proline
Molecular Formula:
C5H7NO3
EINECS:
223-735-0
brands:
boss
Assay:
99%min
usage:
pharmaceutical use
Package:
25kg/ drum
Packaging&Delivery
Packaging Details
5kg/drum, 10kg/drum,25kg/drum,200kg/drum
Port
shanghai, tianjin,qingdao

Property

CAS No.: 4042-36-8 Formula: C5H7NO3 Molecular Weight: 129.11400

Description

Pyroglutamic acid (also known as PCA, 5-oxoproline, pidolic acid, or pyroglutamate for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam. It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N-terminals which present a problem for N-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N-terminus by cleaving off the pyroglutamate residue.
Pyroglutamic acid, also known as pidolic acid, exists as two distinct enantiomers:

Basic Info

Chemical Name	5-oxo-D-proline
Synonyms	D-Glutamic Acid Lactam; D-(+)-Pyroglutamic Acid; (R)-5-Oxopyrrolidine-2-carboxylic acid; (R)-(+)-2-Pyrrolidinone-5-Carboxylic Acid; (2R)-5-oxopyrrolidine-2-carboxylic acid; D-Pyroglutamic Acid; (R)-2-Pyrrolidone-5-carboxylic Acid;
CAS No.	4042-36-8
Molecular Formula	C5H7NO3
Molecular Weight	129.11400
PSA	66.40000
LogP	-0.32160

Properties

Appearance & Physical State	White crystals with lumps
Density	1.38g/cm3
Boiling Point	453.1ºC at 760mmHg
Melting Point	155-162ºC
Flash Point	227.8ºC
Storage Condition	Store at 0-5ºC
Vapor Pressure	0.002mmHg at 25°C

Safety Info

Safety Statements	S26-S37/39
HS Code	2933790090
Risk Statements	R36/37/38
Hazard Codes	Xi
Caution Statement	P261; P305 + P351 + P338
Symbol	GHS07
Hazard Declaration	H315; H319; H335
Signal Word	Warning

Synthesis Route

(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone→5-oxo-D-proline
tert-butyl (4R,4'R,5'S)-4-amino-5-(3',4'-dimethyl-2'-oxo-5'-phenyl-1'-imidazolydinyl)-5-oxopentanoate→5-oxo-D-proline
Methyl (R)-2-pyrrolidone-5-carboxylate→5-oxo-D-proline

Precursor

(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
Methyl (R)-2-pyrrolidone-5-carboxylate
D-glutamic acid
Ethyl D-(-)-pyroglutamate

Downstream Product

3-(tert-butylamino)propane-1,2-diol
D-glutamic acid
Fasoracetam
(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

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