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(S)-(+)-1-Cbz-3-pyrrolidinol

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Origin: China

Cas No: 100858-32-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 100858-32-0 Formula: C12H15NO3 Molecular Weight: 221.25200

Basic Info

Chemical Name	(S)-(+)-1-Cbz-3-pyrrolidinol
Synonyms	benzyl (3S)-3-hydroxypyrrolidine-1-carboxylate; (S)-N-Z-3-Pyrrolidinol; (S)-1-Carbobenzoxy-3-pyrrolidinol; (S)-1-Benzyloxycarbonyl-3-pyrrolidinol; (S)-(+)-1-Cbz-3-Pyrrolidinol; (S)-1-Cbz-3-pyrrolidinol; (S)-1-Carbobenzoxy-3-hydroxypyrrolidine;
CAS No.	100858-32-0
Molecular Formula	C12H15NO3
Molecular Weight	221.25200
PSA	49.77000
LogP	1.32770

Properties

Density	1.263g/cm3
Boiling Point	370.7ºC at 760mmHg
Melting Point	71-77ºC
Flash Point	178ºC
Refractive Index	1.589
Vapor Pressure	3.75E-06mmHg at 25°C

Safety Info

Safety Statements	S26-S36-S45
HS Code	2933990090
RIDADR	UN 2811
Risk Statements	R25; R36/37/38
Hazard Codes	T

Synthesis Route

Benzyl chloroformate+(S)-3-Hydroxypyrrolidine→(S)-(+)-1-Cbz-3-pyrrolidinol
(R)-1-Carbobenzoxy-3-pyrrolidinol→(S)-(+)-1-Cbz-3-pyrrolidinol
benzyl (3S)-3-acetoxyfluoropyrrolidine-1-carboxylate→(S)-(+)-1-Cbz-3-pyrrolidinol

Precursor

Benzyl chloroformate
(S)-3-Hydroxypyrrolidine
(S)-3-Hydroxypyrrolidine hydrochloride
(R)-1-Carbobenzoxy-3-pyrrolidinol

Downstream Product

benzyl (3R)-3-fluoropyrrolidine-1-carboxylate
(3R)-1-N-Cbz-3-Aminopyrrolidine
benzyl (3R)-3-cyanopyrrolidine-1-carboxylate
(R)-1-Cbz-3-Boc-Aminopyrrolidine

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