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zalcitabine

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Origin: China

Cas No: 7481-89-2

Specification: 99%min

Min order Quantity: 1 /kg

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 7481-89-2 Formula: C9H13N3O3 Molecular Weight: 211.21800

    Description

    Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse transcriptase inhibitor (NARTI) sold under the trade name Hivid. Zalcitabine was the third antiretroviral to be approved by the Food and Drug Administration (FDA) for the treatment of HIV/AIDS. It is used as part of a combination regimen.
    Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries.

    Basic Info

    Chemical Name zalcitabine
    Synonyms

    ddCyd;
    [3H]-Zalcitabine;
    ddC;
    2',3'-DIDEOXYCYTIDINE;
    Zalcitabine;
    4-amino-1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;
    HIVID;
    Cytidine,2',3'-dideoxy;
    Dideoxycytidine;
    Zalcitibine;
    2',3'-Dideoxycytidinene;
    ddC (Antiviral);

    CAS No. 7481-89-2
    Molecular Formula C9H13N3O3
    Molecular Weight 211.21800
    PSA 90.37000
    LogP 0.07660

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.57 g/cm3
    Boiling Point 415ºC at 760 mmHg
    Melting Point 210-214ºC
    Flash Point 204.8ºC
    Refractive Index 78 ° (C=0.5, H2O)
    Water Solubility 5-10 g/100 mL at 19 ºC
    Stability Stable. Combustible. Incompatible with strong oxidizing agents.
    Storage Condition 2-8ºC

    Safety Info

    RTECS HA3870000
    Safety Statements S22-S36
    HS Code 2934999090
    WGK Germany 3
    Risk Statements R40
    Hazard Codes Xn
    Caution Statement P281
    Hazard Declaration H351
    Signal Word Warning
    Symbol GHS08

    Synthesis Route

    Dideoxycytidinene→zalcitabine
    N4-acetyl-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)cytosine→zalcitabine
    5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxycytidine→zalcitabine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Rodent - rat 188 gm/kg/94D-I 1.Blood-changes in bone marrow (not otherwise specified)
    2.Blood-changes in erythrocyte (RBC) count
    3.Blood-changes in leukocyte (WBC) count
    Oral TDLo - Lowest published toxic dose Rodent - mouse 94 gm/kg/94D-I 1.Blood-other changes
    2.Blood-changes in other cell count (unspecified)
    3.Blood-changes in erythrocyte (RBC) count
    Oral TDLo - Lowest published toxic dose Rodent - mouse 14500 mg/kg/29D-I 1.Blood-other changes
    2.Blood-changes in other cell count (unspecified)
    3.Blood-changes in erythrocyte (RBC) count

    Precursor

    Dideoxycytidinene
    N4-acetyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxycytidine
    5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxycytidine
    N4-acetyl-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)cytosine

    Downstream Product

    2',3'-Dideoxyuridine

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