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Rosuvastatin

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Origin: China

Cas No: 287714-41-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    287714-41-4
    Other Names:
    Rosuvastatin Intermediates
    MF:
    C22H24D3FN3NaO6S
    EINECS No.:
    1806241-263-5
    Place of Origin:
    Shaanxi, China
    Type:
    Blood System Agents
    Grade Standard:
    Medicine Grade, Medical Grade
    Brand Name:
    Rosuvastatin Intermediates
    Model Number:
    Rosuvastatin Intermediates
    Purity:
    99%min
    Product Name:
    Rosuvastatin Intermediates
    CAS:
    287714-41-4
    Appearance:
    White Powder
    Specification:
    99.0%min
    Molecular Formula:
    C22H24D3FN3NaO6S
    Molecular Weight:
    481.54
    Test Method:
    HPLC
    Sample:
    Available
    Shelf Life:
    2 Years

    Packaging&Delivery

    Packaging Details
    1.solid, powder, paste products: 0.5kg, 1kg, 2kg, 5kg / sealed aluminum foil bag; 25kg / cardboard drum.
    2. liquid: in line with national safety standards and logistics requirements of the sealed barrels.
    3. can also be customized according to customer requirements.
    Port
    shanghai ningbo
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)3To be negotiated

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  • Property

    CAS No.: 287714-41-4 Formula: C22H28FN3O6S Molecular Weight: 481.53800

    Description

    Rosuvastatin, marketed as Crestor, is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions, and to prevent cardiovascular disease.
    It was developed by Shionogi. In 2013 Crestor was the fourth-highest selling drug in the United States, accounting for approx. $5.2 billion in sales. A generic version became available in the United States in 2016.

    Basic Info

    Chemical Name Rosuvastatin
    Synonyms

    X-Plended;
    7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid;
    (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid;
    ZD 4522;
    Crestor;

    CAS No. 287714-41-4
    Molecular Formula C22H28FN3O6S
    Molecular Weight 481.53800
    PSA 149.30000
    LogP 3.48250

    Properties

    Density 1.368 g/cm3
    Boiling Point 745.6ºC at 760 mmHg
    Flash Point 404.7ºC
    Refractive Index 1.597
    Vapor Pressure 2.38E-23mmHg at 25°C

    Synthesis Route

    (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid methylammonium salt→Rosuvastatin
    7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester→Rosuvastatin
    tert-butyl 2-[6-[(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→Rosuvastatin

    Precursor

    tert-butyl 2-[6-[(E)-2-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]ethenyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
    (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid iso-propylammonium salt
    7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
    rosuvastatin α,α-dimethylphenethyl ester

    Downstream Product

    Rosuvastatin Lactone

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