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3,5-Di(tert-butyldimethylsilyl) Rosuvastatin

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Origin: China

Cas No: 1353050-10-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 1353050-10-8 Formula: C34H56FN3O6SSi2 Molecular Weight: 710.05900

Description

Intermediate in the preparation of Rosuvastatin metabolites.

Basic Info

Chemical Name	3,5-Di(tert-butyldimethylsilyl) Rosuvastatin
Synonyms	(E,3S,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]hept-6-enoic acid;
CAS No.	1353050-10-8
Molecular Formula	C34H56FN3O6SSi2
Molecular Weight	710.05900
PSA	127.30000
LogP	9.54150

Synthesis Route

(3R,5S,E)-methyl 3,5-bis(tert-butyldimethylsilyloxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)hept-6-enoate→3,5-Di(tert-butyldimethylsilyl) Rosuvastatin
methyl (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate→3,5-Di(tert-butyldimethylsilyl) Rosuvastatin

Precursor

methyl (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
(3R,5S,E)-methyl 3,5-bis(tert-butyldimethylsilyloxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)hept-6-enoate

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3,5-Di(tert-butyldimethylsilyl) Rosuvastatin

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