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Entecavir

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Origem: China

Cas No: 142217-69-4

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Especificação de produtos
  • Descrição do produto
  • Property

    CAS No.: 142217-69-4 Formula: C12H15N5O3 Molecular Weight: 277.27900

    Description

    Entecavir INN, abbreviated ETV, is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. More specifically, it is a deoxyguanosine analogue belonging to a class of carbocyclic nucleosides, that inhibits reverse transcription, DNA replication and transcription in the viral replication process.

    Basic Info

    Chemical Name Entecavir
    Synonyms

    2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one;
    Baraclude;
    UNII-NNU2O4609D;
    Entecavir(anhydrous);

    CAS No. 142217-69-4
    Molecular Formula C12H15N5O3
    Molecular Weight 277.27900
    PSA 130.05000
    LogP -0.24660

    Properties

    Appearance & Physical State white to off-white/yellow crystalline powder
    Density 1.81g/cm3
    Boiling Point 734.2ºC at 760 mmHg
    Melting Point 249-252ºC
    Flash Point 397.9ºC
    Refractive Index 1.837

    Safety Info

    HS Code 2933990090

    Synthesis Route

    6-chloroentecavirEntecavir
    tert-butyl (6-iodo-9-((4aR,6S,7aS)-2-methyl-5-methylenehexahydrocyclopenta[d][1,3]dioxin-6-yl)-9H-purin-2-yl)carbamateEntecavir
    6-(benzyloxy)-9-((4aR,6S,7aS)-5-methylene-2-phenylhexahydrocyclopenta[d][1,3]dioxin-6-yl)-N-(trimethylsilyl)-9H-purin-2-amineEntecavir

    Precursor

    9-[(1S,3R,4S)-4-tert-butyldimethylsilyloxy-3-(tert-butyldimethylsilyloxymethyl)-2-methylene-cyclopentyl]-6-chloro-9H-purine-2-carbamic acid tert-butyl ester
    6-(benzyloxy)-9-((4aR,6S,7aS)-5-methylene-2-phenylhexahydrocyclopenta[d][1,3]dioxin-6-yl)-N-(trimethylsilyl)-9H-purin-2-amine
    6-chloroentecavir
    tert-butyl (6-iodo-9-((4aR,6S,7aS)-2-methyl-5-methylenehexahydrocyclopenta[d][1,3]dioxin-6-yl)-9H-purin-2-yl)carbamate

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