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Rosuvastatin Lactone

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Origin: China

Cas No: 503610-43-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 503610-43-3 Formula: C22H26FN3O5S Molecular Weight: 463.52200

    Description

    Intermediate in the production of Rosuvastatin derivatives.

    Basic Info

    Chemical Name Rosuvastatin Lactone
    Synonyms

    RosuvastatinLactone;
    (3R,5R)-ROSUVASTATIN LACTONE;
    Rosuvastatin lactone;
    ROSUVASTATIN-5S-LACTONE;

    CAS No. 503610-43-3
    Molecular Formula C22H26FN3O5S
    Molecular Weight 463.52200
    PSA 118.07000
    LogP 3.96240

    Synthesis Route

    Rosuvastatin→Rosuvastatin Lactone
    2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl )-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate methyl ester→Rosuvastatin Lactone
    (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid methylammonium salt→Rosuvastatin Lactone

    Precursor

    2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl )-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate methyl ester
    E-(6-{2-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]vinyl}-[(4R,6S)-2,2-dimethyl-[1,3]dioxan-4-yl])-N-methoxy-N-methyl-acetamide
    Rosuvastatin
    (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-heptenoic acid methylammonium salt

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