Home > Organosulfur Compounds> N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester

N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester

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Origin: China

Cas No: 88043-21-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 88043-21-4 Formula: C18H25NO7S Molecular Weight: 399.45900

Description

4-Hydroxy-L-proline derivative. Used in the preparation of bicycloazahydantoins, as androgen receptor antagonists

Basic Info

Chemical Name	N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester
Synonyms	1-O-tert-butyl 2-O-methyl (2S,4R)-4-(4-methylphenyl)sulfonyloxypyrrolidine-1,2-dicarboxylate;
CAS No.	88043-21-4
Molecular Formula	C18H25NO7S
Molecular Weight	399.45900
PSA	107.59000
LogP	3.27000

Properties

Density	1.265 g/cm3
Boiling Point	520.5ºC at 760 mmHg
Flash Point	268.6ºC

Safety Info

HS Code	2933990090
Symbol	GHS07
Hazard Declaration	H319
Caution Statement	P305 + P351 + P338
Signal Word	Warning

Synthesis Route

N-Boc-trans-4-Hydroxy-L-proline methyl ester+p-Toluenesulfonyl chloride→N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester
1-(t-butoxycarbonyl)-4-hydroxyproline+p-Toluenesulfonyl chloride→N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester
N-Boc-trans-4-hydroxy-L-proline methyl ester hydrochloride+p-Toluenesulfonyl chloride→N-Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester

Precursor

N-Boc-trans-4-hydroxy-L-proline methyl ester hydrochloride
N-Boc-trans-4-Hydroxy-L-proline methyl ester
p-Toluenesulfonyl chloride
1-(t-butoxycarbonyl)-4-hydroxyproline

Downstream Product

1-O-tert-butyl 2-O-methyl (2S,4S)-4-cyanopyrrolidine-1,2-dicarboxylate
Boc-trans-4-cyano-L-proline methyl ester
(2S,4S)-1-tert-Butyl 2-methyl 4-aminopyrrolidine-1,2-dicarboxylate
(2S,4S)-1-tert-Butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate

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