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Home > Heterocyclic Compounds> N-Cbz-L-4-Hydroxyproline methyl ester
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N-Cbz-L-4-Hydroxyproline methyl ester

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Origin: China

Cas No: 64187-48-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    64187-48-0
    MF:
    64187-48-0
    EINECS No.:
    64187-48-0
    Place of Origin:
    China
    Type:
    Pharmaceutical Intermediates
    Purity:
    0.99
    Brand Name:
    Leji
    Model Number:
    CAS No. 64187-48-0
    Application:
    Pharmaceutical intermediates
    Appearance:
    powder
    Product Name:
    CAS No. 64187-48-0
    Type of product:
    pharmaceutical raw material
    Grade:
    Medical Grade
    Density:
    085 G/cm3
    Shelf life:
    2 Years
    Storage:
    Room temperature
    MOQ:
    1 Kg

    Packaging&Delivery

    Selling Units:
    Single item
    Single package size: 
    15X10X10 cm
    Single gross weight:
    1.000 kg
    Package Type:
    According to the customer demand
    Lead Time:
    Quantity(Kilograms)1 - 10>10
    Est. Time(days)5To be negotiated

  • Property

    CAS No.: 64187-48-0 Formula: C14H17NO5 Molecular Weight: 279.28800

    Description

    N-(Benzyloxycarbonyl)-4-hydroxyproline Methyl Ester, can be used as an intermediate in the synthesis of various pharmaceutical and biologically active compounds. It is used in the synthesis of Doripenem, an Antibacterial agent.

    Basic Info

    Chemical Name N-Cbz-L-4-Hydroxyproline methyl ester
    Synonyms

    Z-HYP-OME;

    CAS No. 64187-48-0
    Molecular Formula C14H17NO5
    Molecular Weight 279.28800
    PSA 76.07000
    LogP 0.86930

    Properties

    Density 1.313 g/cm3
    Boiling Point 422.779ºC at 760 mmHg
    Flash Point 209.49ºC
    Refractive Index 1.572
    Storage Condition -20ºC

    Safety Info

    HS Code 2933990090

    Synthesis Route

    Methanol+N-Cbz-Hydroxy-L-proline→N-Cbz-L-4-Hydroxyproline methyl ester
    (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride+Benzyl chloroformate→N-Cbz-L-4-Hydroxyproline methyl ester
    N-(Benzyloxycarbonyloxy)succinimide+(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride→N-Cbz-L-4-Hydroxyproline methyl ester

    Precursor

    Benzyl chloroformate
    N-Cbz-Hydroxy-L-proline
    N-(Benzyloxycarbonyloxy)succinimide
    (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

    Downstream Product

    cis-4-hydroxy-L-proline
    (2S,4S)-1-((Benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
    methyl (2S,4R)-4-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrolidine-2-carboxylate
    benzyl (2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

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