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N-Boc-trans-4-Hydroxy-L-proline methyl ester

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Origin: China

Cas No: 74844-91-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
74844-91-0
Other Names:
CAS 74844-91-0
MF:
C11H19NO5
EINECS No.:
74844-91-0
Place of Origin:
Shandong, China
Type:
Agrochemical Intermediates
Purity:
99%
Brand Name:
FinerChem
Model Number:
74844-91-0
Application:
Organic Intermediate
Appearance:
White powder
CAS:
74844-91-0
Product name:
N-Boc-trans-4-Hydroxy-L-proline methyl ester
Appearence:
White powder
Molecular formula:
C11H19NO5
Molecular weight:
245.27
Packaging&Delivery
Packaging Details
Aluminum foil bag for within 10kg
Fiber drum for 10kg and more
Shipping: By air, by sea or by courier (VIP account of TNT, DHL, Fedex and EMS)
Port
Qingdao or Shanghai
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 2 To be negotiated

Property

CAS No.: 74844-91-0 Formula: C11H19NO5 Molecular Weight: 245.27200

Description

(2S,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl Ester 2-Methyl Ester is used in the synthesis of For-Met-Leu-Phe-OMe (fMLF-OMe) analogues based on Met residue replacement by 4-amino-proline scaffold.

Basic Info

Chemical Name	N-Boc-trans-4-Hydroxy-L-proline methyl ester
Synonyms	N-BOC-transydro-L-prolinemethylester; N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER; N-BOC-L-Hydroxyproline methyl ester; BOC-HYDROXYPROLINE-OME; BOC-L-4-HYDROXYPROLINE METHYL ESTER; N-Boc-trans-hydro-L-prolinemethylester; N-Boc-trans-4-Hydroxy-L-prolinemethylester; Boc-Hyp-Ome; BOC-L-HYDROXYPROLINE METHYL ESTER; BOC-L-T-4-HYDROXYPROLINE METHYL ESTER; Boc-trans-4-hydroxy-L-proline methyl ester;
CAS No.	74844-91-0
Molecular Formula	C11H19NO5
Molecular Weight	245.27200
PSA	76.07000
LogP	0.46760

Properties

Appearance & Physical State	white or off-white powder
Density	1.216 g/cm3
Boiling Point	335.2ºC at 760 mmHg
Melting Point	91-96ºC
Flash Point	156.6ºC
Refractive Index	1.501
Storage Condition	2-8ºC

Safety Info

Safety Statements	S24/25
HS Code	2933990090
WGK Germany	3
Risk Statements	R20/21/22
Hazard Codes	Xn

Synthesis Route

1-(tert-butyl) 2-methyl (2S,4R)-4-(((methylthio)carbonothioyl)oxy)pyrrolidine-1,2-dicarboxylate→N-Boc-trans-4-Hydroxy-L-proline methyl ester+1-O-tert-butyl 2-O-methyl (2S)-2,5-dihydropyrrole-1,2-dicarboxylate
tert-butoxycarbonyl anhydride+(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride→N-Boc-trans-4-Hydroxy-L-proline methyl ester
Boc-L-Hydroxyproline+iodomethane→N-Boc-trans-4-Hydroxy-L-proline methyl ester

Precursor

iodomethane
Boc-L-Hydroxyproline
methyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate
tert-butoxycarbonyl anhydride

Downstream Product

1-O-tert-butyl 2-O-methyl (2S,4S)-4-cyanopyrrolidine-1,2-dicarboxylate
4-hydroxy-L-proline
(2S,4R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenylpyrrolidine-2-carboxylic acid
1-[(2-methylpropan-2-yl)oxycarbonyl]-4-naphthalen-2-yloxypyrrolidine-2-carboxylic acid

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