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topiramate

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Origem: China

Cas No: 97240-79-4

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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  • Especificação de produtos
  • Descrição do produto

  • Quick Details

    CAS No.:
    97240-79-4
    Other Names:
    Topiramate powder
    MF:
    C12H21NO8S
    EINECS No.:
    200-659-6
    Place of Origin:
    china anhui
    Type:
    Auxiliaries and Other Medicinal Chemicals
    Grade Standard:
    Medicine Grade, Cosmetic Grade
    Brand Name:
    puya
    Model Number:
    top
    Purity:
    99%
    Density:
    0.9337
    Color:
    White Color
    Boiling point:
    132.32°C

    Packaging&Delivery

    Port
    shanghai

  • Property

    CAS No.: 97240-79-4 Formula: C12H21NO8S Molecular Weight: 339.36200

    Description

    Used as an anticonvulsant.

    Basic Info

    Chemical Name topiramate
    Synonyms

    Topamax Sprinkle;
    Topiramate;
    Topimax;
    Topamax;
    Epitomax;
    McN-4853;
    Topomax;
    [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate;
    Tipiramate;
    Topiramatum;

    CAS No. 97240-79-4
    Molecular Formula C12H21NO8S
    Molecular Weight 339.36200
    PSA 123.92000
    LogP 1.38570

    Properties

    Appearance & Physical State white to off-white crystalline powder
    Density 1.336 g/cm3
    Boiling Point 438.7ºC at 760 mmHg
    Melting Point 125ºC
    Flash Point 219.1ºC
    Refractive Index 1.497
    Stability Stable if stored as directed.
    Storage Condition 2-8ºC

    Safety Info

    RTECS LS7083000
    Safety Statements S26; S36
    WGK Germany 3
    Risk Statements R36/37/38
    Hazard Codes Xn
    Hazard Declaration H315; H319; H335
    Caution Statement P261; P305 + P351 + P338
    Symbol GHS07
    Signal Word Warning

    Synthesis Route

    (3aS,5aR,8aR,8bS)-3a-(chlorosulfonyloxymethyl)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran→topiramate
    Diacetonefructose→topiramate
    [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl N-diazosulfamate→topiramate

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat >1500 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl N-diazosulfamate
    N-[(diethylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
    Diacetonefructose
    N-(2-methoxycarbonylphenyl)carbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

    Downstream Product

    [(3aS,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-5,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-b]pyran-3a-yl]methyl sulfamate

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