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topiramate

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Origin: China

Cas No: 97240-79-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
97240-79-4
Other Names:
Topiramate powder
MF:
C12H21NO8S
EINECS No.:
200-659-6
Place of Origin:
china anhui
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade, Cosmetic Grade
Brand Name:
puya
Model Number:
top
Purity:
99%
Density:
0.9337
Color:
White Color
Boiling point:
132.32°C
Packaging&Delivery
Port
shanghai

Property

CAS No.: 97240-79-4 Formula: C12H21NO8S Molecular Weight: 339.36200

Description

Used as an anticonvulsant.

Basic Info

Chemical Name	topiramate
Synonyms	Topamax Sprinkle; Topiramate; Topimax; Topamax; Epitomax; McN-4853; Topomax; [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl sulfamate; Tipiramate; Topiramatum;
CAS No.	97240-79-4
Molecular Formula	C12H21NO8S
Molecular Weight	339.36200
PSA	123.92000
LogP	1.38570

Properties

Appearance & Physical State	white to off-white crystalline powder
Density	1.336 g/cm3
Boiling Point	438.7ºC at 760 mmHg
Melting Point	125ºC
Flash Point	219.1ºC
Refractive Index	1.497
Stability	Stable if stored as directed.
Storage Condition	2-8ºC

Safety Info

RTECS	LS7083000
Safety Statements	S26; S36
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xn
Hazard Declaration	H315; H319; H335
Caution Statement	P261; P305 + P351 + P338
Symbol	GHS07
Signal Word	Warning

Synthesis Route

(3aS,5aR,8aR,8bS)-3a-(chlorosulfonyloxymethyl)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran→topiramate
Diacetonefructose→topiramate
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl N-diazosulfamate→topiramate

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	>1500 mg/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyl-5,5a,8a,8b-tetrahydrodi[1,3]dioxolo[4,5-a:5',3'-d]pyran-3a-yl]methyl N-diazosulfamate
N-[(diethylamino)carbonyl]-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Diacetonefructose
N-(2-methoxycarbonylphenyl)carbonyl-2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

Downstream Product

[(3aS,6R,7R,7aS)-6,7-dihydroxy-2,2-dimethyl-5,6,7,7a-tetrahydro-[1,3]dioxolo[4,5-b]pyran-3a-yl]methyl sulfamate

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