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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 7-hydroxy-3,4-dihydro-1H-quinolin-2-one
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7-hydroxy-3,4-dihydro-1H-quinolin-2-one

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Origin: China

Cas No: 22246-18-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    22246-18-0
    Other Names:
    3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
    MF:
    C9H9NO2
    EINECS No.:
    22246-18-0
    Place of Origin:
    Hebei, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99%
    Brand Name:
    minshang
    Model Number:
    22246-18-0
    Application:
    Pharmaceutical Intermediates
    Appearance:
    liquid
    Product name:
    3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
    CAS:
    22246-18-0
    Color:
    white
    Molecular Weight:
    163.173
    EINECS:
    22246-18-0
    MOQ:
    1g
    Payment terms:
    WU,BTC,Moneygram
    Package:
    box

    Packaging&Delivery

    Packaging Details
    box,
    bag
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)3To be negotiated

    Products Description

    Product Name
    3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
    Cas number
    22246-18-0
    Appearance
    white powder
    Molecular Weight
    163.173
    Boiling Point
    403.7±45.0 °C at 760 mmHg
    Molecular Formula
    C9H9NO2
    Melting Point
    233-237 °C
    Flash Point
    198.0±28.7 °C

  • Property

    CAS No.: 22246-18-0 Formula: C9H9NO2 Molecular Weight: 163.17300

    Description

    An antitumor agent. Hydroxyindole analog inhibitor tyrosinase melanoma. This compound is also used in the preparation of aripiprazole.

    Basic Info

    Chemical Name 7-hydroxy-3,4-dihydro-1H-quinolin-2-one
    Synonyms

    3,4-Dihydro-7-hydroxycarbostyril;
    7-Hydroxy-3,4-dihydroquinolin-2(1H)-one;
    7-Hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline;
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone;
    7-Hydroxy-3,4-dihydro-quinolin-2-one;
    7-hydroxy-3,4-dihydro-2-quinolinone;
    7-Hydroxy-3,4-dihydro carbostyril;
    3,4-Dihydro-7-hydroxy-2(1H)-quinolinone;

    CAS No. 22246-18-0
    Molecular Formula C9H9NO2
    Molecular Weight 163.17300
    PSA 49.33000
    LogP 1.41490

    Properties

    Appearance & Physical State White powder
    Density 1.282 g/cm3
    Boiling Point 403.7ºC at 760 mmHg
    Melting Point 233-237ºC
    Flash Point 198ºC

    Safety Info

    Safety Statements S36/37
    HS Code 2933499090
    Risk Statements R22; R43
    Hazard Codes Xi; Xn
    Hazard Declaration H302; H317
    Symbol GHS07
    Signal Word Warning
    Caution Statement P280

    Synthesis Route

    3-Chloro-N-(3-methoxyphenyl)propanamide→7-hydroxy-3,4-dihydro-1H-quinolin-2-one+5-Hydroxy-3,4-dihydro-2(1H)-quinolinone
    3-Chloro-N-(3-methoxyphenyl)propanamide→7-hydroxy-3,4-dihydro-1H-quinolin-2-one
    3-chloro-N-(3-hydroxyphenyl)propanamide→7-hydroxy-3,4-dihydro-1H-quinolin-2-one

    Precursor

    3-chloro-N-(3-hydroxyphenyl)propanamide
    3-(4-hydroxy-2-nitrophenyl)acrylic acid
    3-Methoxyaniline
    3-Chloropropionyl chloride

    Downstream Product

    3,4-Dihydro-7-(4-bromobutoxy)-2(1H)-quinolinone
    7-(4-Chlorobutoxy)-3,4-dihydroquinolin-2(1H)-one
    1,2,3,4-tetrahydroquinolin-7-ol
    6-Bromo-7-hydroxy-3,4-dihydro-1H-quinolin-2-one

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