Home > Aromatic Compounds> (2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

(2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

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Origin: China

Cas No: 5545-52-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

Quick Details
CAS No.:
5545-52-8
MF:
5545-52-8
EINECS No.:
5545-52-8
Type:
Pharmaceutical Intermediates
Purity:
0.99
Application:
Pharmaceutical intermediates
Appearance:
powder
Product Name:
CAS No. 5545-52-8
Type of product:
pharmaceutical raw material
Grade:
Medical Grade
Packaging&Delivery
Selling Units:
Single item
Single package size:
15X10X10 cm
Single gross weight:
1.000 kg
Package Type:
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According to the customer demand
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Lead Time:
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 5 To be negotiated

Property

CAS No.: 5545-52-8 Formula: C16H21NO6 Molecular Weight: 323.34100

Description

(S)-3-(((Benzyloxy)carbonyl)amino)-5-isopropoxy-5-oxopentanoic Acid has been used for the preparation of β-protected aspartate and γ-protected glutamate.

Basic Info

Chemical Name	(2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid
Synonyms	Z-L-Aspartic acid 4-tert-butyl ester; Z-Asp(Ot-Bu)-OH,H2O; N-Cbz-L-aspartic acid 4-tert-butyl ester; Cbz-L-Aspartic 4-tert-butyl ester; Z-Asp-OtBu; Cbz-L-aspartic acid 4-tert-butyl ester; Z-Asp(OtBu)-OH.DCHA;
CAS No.	5545-52-8
Molecular Formula	C16H21NO6
Molecular Weight	323.34100
PSA	101.93000
LogP	2.48870

Properties

Appearance & Physical State	White Powder
Density	1.219 g/cm3
Boiling Point	513.1ºC at 760 mmHg
Melting Point	76.7ºC
Flash Point	264.1ºC
Refractive Index	1.526
Storage Condition	-20ºC

Safety Info

Safety Statements	S22-S24/25
WGK Germany	3

Synthesis Route

(S)-4-tert-Butyl 1-methyl 2-(((benzyloxy)carbonyl)amino)succinate→(2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid
(S)-3-benzyloxycarbonyl-5-oxo-4-oxazolidine acetic acid tert-butyl ester→(2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid
tert-Butyl acetate+N-Carbobenzyloxy-L-aspartic acid→+(2S)-4-[(2-methylpropan-2-yl)oxy]-4-oxo-2-(phenylmethoxycarbonylamino)butanoic acid

Precursor

(S)-4-tert-Butyl 1-methyl 2-(((benzyloxy)carbonyl)amino)succinate
tert-Butyl acetate
1-O-benzyl 4-O-tert-butyl (2S)-2-aminobutanedioate
N-Carbobenzyloxy-L-aspartic acid

Downstream Product

tert-butyl (3S)-5-bromo-4-oxo-3-(phenylmethoxycarbonylamino)pentanoate
(3S)-4-methoxy-4-oxo-3-(phenylmethoxycarbonylamino)butanoic acid
(2S)-2-amino-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid
4-O-tert-butyl 1-O-(2,5-dioxopyrrolidin-1-yl) (2S)-2-(phenylmethoxycarbonylamino)butanedioate

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