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2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole

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Origin: China

Cas No: 3613-73-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 3613-73-8 Formula: C21H25N3 Molecular Weight: 319.44300

Description

Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.
Research was conducted in both Russia and western nations into potential applications as a neuroprotective drug to treat Alzheimer's disease and, possibly, as a nootropic, as well. After a major phase III clinical trial for Alzheimer's disease (AD) treatment failed to show any benefit, three other AD trials continued. Major industry-based development in this indication essentially stopped after another Phase III trial suffered the same fate in 2012. Dimebon failed in the phase III trial for Huntington disease.

Basic Info

Chemical Name	2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
Synonyms	Dimebolin; Dimebon; aka latrepiridine; Dimebone; Latrepirdine; Dimeboline; Preparation 84;
CAS No.	3613-73-8
Molecular Formula	C21H25N3
Molecular Weight	319.44300
PSA	21.06000
LogP	3.82160

Properties

Appearance & Physical State	White powder
Density	1.13 g/cm3
Boiling Point	505.7ºC at 760 mmHg
Flash Point	259.7ºC

Synthesis Route

2-Methyl-5-vinylpyridine+2,8-dimethyl-1,3,4,5-tetrahydropyrido[4,3-b]indole→2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine→2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
tert-butyl 8-methyl-5-(2-(6-methylpyridin-3-yl)ethyl)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate→2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole

Precursor

2,8-dimethyl-1,3,4,5-tetrahydropyrido[4,3-b]indole
1-Methyl-4-piperidone
2-Methyl-5-vinylpyridine
N'-(1-methyl-piperidin-4-ylidene)-N-[2-(6-methyl-pyridin-3-yl)-ethyl]-N-p-tolyl-hydrazine

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