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amoxapine

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Origin: China

Cas No: 14028-44-5

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 14028-44-5 Formula: C17H16ClN3O Molecular Weight: 313.78100

    Description

    Amoxapine (Notable brand names include: Asendin, Asendis, Defanyl, Demolox. See here for more brand name information) is a tetracyclic antidepressant of the dibenzoxazepine family, though it is often classified as a secondary amine tricyclic antidepressant. It is the N-demethylated metabolite of loxapine. It first received marketing approval in the US in 1992 (approximately thirty to forty years after most of the other tricyclic antidepressants were introduced in the US).

    Basic Info

    Chemical Name amoxapine
    Synonyms

    Asendis;
    Demolox;
    N-desmethylloxapine;
    Defanyl;
    2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine;
    2-Chlor-11-(1-piperazinyl)dibenz<b.f><1.4>oxazepin;
    Moxadil;
    2-Chloro-11-(1-piperazinyl)dibenzo[b,f][1,4]oxazepine;
    Amoxapine;
    Amoxapinum;
    Asendin;
    8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine;
    Amoxapina;
    Amoxan;
    Amoxepine;

    CAS No. 14028-44-5
    Molecular Formula C17H16ClN3O
    Molecular Weight 313.78100
    PSA 36.86000
    LogP 3.13150

    Properties

    Appearance & Physical State White solid
    Density 1.37g/cm3
    Boiling Point 469.9ºC at 760mmHg
    Melting Point 175-176ºC
    Flash Point 238ºC
    Refractive Index 1.685
    Stability Stable at normal temperatures and pressures.
    Storage Condition Keep tightly closed.
    Vapor Pressure 5.32E-09mmHg at 25°C

    Safety Info

    RTECS HQ4025500
    Hazard Class 6.1(b)
    Safety Statements S36
    HS Code 2934999090
    Packing Group III
    WGK Germany 3
    RIDADR UN 3249
    Risk Statements R22
    Hazard Codes Xn
    Hazard Declaration H302
    Symbol GHS07
    Signal Word Warning

    Synthesis Route

    loxapineamoxapine
    2-Chloro-10,11-dihydro-11-oxo-dibenzo[b,f][1,4]oxazepineamoxapine
    piperazine+2,11-dichloro-dibenzo[b,f][1,4]oxazepineamoxapine

    Precursor

    2,11-dichloro-dibenzo[b,f][1,4]oxazepine
    loxapine
    2-Chloro-10,11-dihydro-11-oxo-dibenzo[b,f][1,4]oxazepine
    piperazine

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