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Olopatadine

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Origin: China

Cas No: 113806-05-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 113806-05-6 Formula: C21H23NO3 Molecular Weight: 337.41200

    Description

    Olopatadine hydrochloride is an antihistamine (as well as anticholinergic and mast cell stabilizer), sold as a prescription eye drop manufactured by Alcon in one of three strengths: 0.7% solution or Pazeo in the US, 0.2% solution or Pataday (also called Patanol S in some countries), and 0.1% or Patanol (also called Opatanol in some countries). It is used to treat itching associated with allergic conjunctivitis (eye allergies). A decongestant nasal spray formulation is sold as Patanase, which was approved by the FDA on April 15, 2008. It is also available as an oral tablet in Japan under the tradename Allelock, manufactured by Kyowa Hakko Kogyo.
    It should not be used to treat irritation caused by contact lenses. The usual dose for Patanol is 1 drop in each affected eye 2 times per day, with 6 to 8 hours between doses. Both Pazeo and Pataday are dosed 1 drop in each eye daily.
    There is potential for Olopatadine as a treatment modality for steroid rebound (red skin syndrome).
    Olopatadine was developed by Kyowa Hakko Kogyo.

    Basic Info

    Chemical Name Olopatadine
    Synonyms

    KW 4679;
    Olopatatadine;

    CAS No. 113806-05-6
    Molecular Formula C21H23NO3
    Molecular Weight 337.41200
    PSA 49.77000
    LogP 3.58950

    Properties

    Appearance & Physical State White or off-white crystalline powder
    Density 1.221 g/cm3
    Boiling Point 523ºC at 760 mmHg
    Flash Point 270.1ºC
    Storage Condition Store in original container in a cool dark place.

    Synthesis Route

    (Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid methyl esterOlopatadine
    11-[(Z)-3-(dimethylamino)-propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetamide p-toluensulfonateOlopatadine
    (Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromideOlopatadine

    Precursor

    (Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid methyl ester
    (Z)-11-(3-dimethylaminopropylidene)-6,11-dihydro-dibenz-[b,e]oxepine-2-acetic acid hydrobromide
    (Z)-11-[3-(dimethylamino)propylidene]-6,11-dihydro-dibenz[b,e]oxepin-2-acetic acid butyl ester
    11-[(Z)-3-(dimethylamino)-propylidene]-6,11-dihydrodibenzo[b,e]oxepin-2-acetamide p-toluensulfonate

    Downstream Product

    Olopatadine Carbaldehyde DISCONTINUED
    Olopatadine Hydrochloride

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