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Tramadol

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Origin: China

Cas No: 27203-92-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 27203-92-5 Formula: C16H25NO2 Molecular Weight: 263.37500

Basic Info

Chemical Name	Tramadol
Synonyms	Ralivia flashtab; Tramadolum; Ultram; Ralivia ER; (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol; Tramal; Tridural;
CAS No.	27203-92-5
Molecular Formula	C16H25NO2
Molecular Weight	263.37500
PSA	32.70000
LogP	2.63460

Properties

Melting Point	178-181 °C

Safety Info

RIDADR	UN 2811 6.1/PG 3
Risk Statements	R22

Synthesis Route

ethyl 2-acetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate+3-METHOXYPHENYLMAGNESIUM BROMIDE→2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol+Tramadol
1-bromo-3-methoxybenzene+ethyl 2-acetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate→2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol+Tramadol
ethyl 2-acetyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate+3-anisyllithium→2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol+Tramadol

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Capillary	VF-5MS	-	1991.3	temperature ramp
Capillary	5 % Phenyl methyl siloxane	-	1999.	custom temperature program
Capillary	HP-1	-	1945.	custom temperature program