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tolfenamic acid

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начало: Китай

Кас Но: 13710-19-5

Спецификация: 99%наименьший

минимальный объем заказа: 1 /kg

снабженческая способность: 50 mt/month

опережающий период: OEM 7 дней, пятно 3 дня

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Quick Details
CAS No.:
13710-19-5
Other Names:
Tolfenamic Acid
MF:
C14H12ClNO2
EINECS No.:
N/A
Place of Origin:
Shandong, China
Type:
Cardiovascular Agents
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Xigema
Model Number:
Tolfenamic Acid, API
Purity:
99%min, >99%
Product Name:
Tolfenamic Acid
Grade:
Medicine Grade
Shelf life:
2 Years
Standard:
USP/BP/CP
Color:
White Color
Packaging&Delivery
Packaging Details
1g, 10g, 100g, 1 kg, 10 kg, 25 kg or as your requirement
Port
QINGDAO PORT

Property

CAS No.: 13710-19-5 Formula: C14H12ClNO2 Molecular Weight: 261.70400

Description

Tolfenamic acid (Clotam) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland. Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.
It is used in the UK as a treatment for migraine. It is generally not available in the US. It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals.

Basic Info

Chemical Name	tolfenamic acid
Synonyms	2-[(3-Chloro-2-methylphenyl)amino]benzoic Acid; N-(3-Chloro-ortho-tolyl) anthranilic acid; 2 (3-Chloro-2-methylanilino)benzoic acid; N-(3-Chloro-2-methylphenyl)anthranilic Acid; 2-(3-chloro-2-methylanilino)benzoic acid; Tolfenamic Acid; 2-(3-Chloro-o-toluidino)benzoic Acid;
CAS No.	13710-19-5
Molecular Formula	C14H12ClNO2
Molecular Weight	261.70400
PSA	49.33000
LogP	4.16320

Properties

Density	1.333 g/cm3
Melting Point	210-214ºC
Flash Point	199ºC
Refractive Index	1.658
Stability	Stable at normal temperatures and pressures.
Vapor Pressure	2.66E-07mmHg at 25°C

Safety Info

RTECS	CB2687500
HS Code	2922499990
WGK Germany	3
RIDADR	UN 2811 6.1/PG 3
Risk Statements	R22
Hazard Codes	Xn
Signal Word	Danger
Caution Statement	P301 + P310
Symbol	GHS06
Hazard Declaration	H301

Synthesis Route

+3-Chloro-2-methylaniline→N-(3-chlorotolyl)-anthranilic acid+tolfenamic acid
potassium 2-bromobenzoate+3-Chloro-2-methylaniline→tolfenamic acid

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	225 mg/kg	1.Behavioral-altered sleep time (including change in righting reflex) 2.Behavioral-ataxia 3.Lungs, Thorax, or Respiration-respiratory stimulation
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	238 mg/kg	1.Behavioral-somnolence (general depressed activity) 2.Lungs, Thorax, or Respiration-respiratory stimulation 3.Gastrointestinal-changes in structure or function of salivary glands
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	246 mg/kg	1.Details of toxic effects not reported other than lethal dose value