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t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate

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Origin: China

Cas No: 147489-06-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details

CAS No.:: 147489-06-3

Other Names:: (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4

MF:: C32H36FNO4

EINECS No.:: 147489-06-3

Place of Origin:: Shandong, China

Type:: Agrochemical Intermediates, Dyestuff Intermediates, Flavor & Fragrance Intermediates, Pharmaceutical Intermediates, Syntheses Material Intermediates

Purity:: ≥99%

Brand Name:: FinerChem

Model Number:: 147489-06-3

Application:: Pitavastatin calcium intermediate

Appearance:: White solid

Product name:: (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)

CAS:: 147489-06-3

Assay:: ≥99%

Packaging&Delivery

Packaging Details: Aluminium foil bag for within 10kg, 25kg/Fiber drum, 25kg/kraft bag

Port: SHANGHAI, QINGDAO , BEIJING, SHENZHEN , DALIAN

Lead Time:

Quantity(Kilograms)	1 - 500	>500
Est. Time(days)	4	To be negotiated

Products Description

Product Name	(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester
CAS No.	147489-06-3
Appearance	White solid
Assay	≥99%
Capacity	200mt/year
Min.packing	1gram
Application	Pharmaceutical intermediates
Standard	Export
Brand	Finerchem
More information	Molecular Formula: C32H36FNO4 Molecular Weight: 517.64 CAS Registry Number: 147489-06-3

Property

CAS No.: 147489-06-3 Formula: C32H36FNO4 Molecular Weight: 517.63100

Basic Info

Chemical Name	t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
Synonyms	(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester;
CAS No.	147489-06-3
Molecular Formula	C32H36FNO4
Molecular Weight	517.63100
PSA	57.65000
LogP	7.57350

Properties

Appearance & Physical State	white or almost white power
Density	1.184g/cm3
Boiling Point	604.559ºC at 760 mmHg
Flash Point	319.426ºC
Refractive Index	1.604
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2934999090

Synthesis Route

2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}sulfonyl)benzo[d]thiazole+tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate→t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
2-cyclopropyl-4-(4-fluorophenyl)-3-iodoquinoline+t-butyl (3R,5S,6E)-3,5-isopropylidenedioxy-7-chlorodimethylsilyl-6-heptenoate→t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
tert-Butyl bromoacetate→t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate

Precursor

tert-Butyl bromoacetate
tert-butyl 2-[(4R,6S)-6-formyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate
2-({[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}sulfonyl)benzo[d]thiazole
t-butyl (3R,5S,6E)-3,5-isopropylidenedioxy-7-chlorodimethylsilyl-6-heptenoate

Downstream Product

pitavastatin calcium
Tert-buthyl Pitavastatin

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