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Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

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Origin: China

Cas No: 148901-69-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
148901-69-3
Other Names:
Pitavastatin 3-Oxo Ethyl Ester
MF:
C27H26FNO4
EINECS No.:
604-664-8
Place of Origin:
Shandong, China
Type:
Pharmaceutical Intermediates
Purity:
99%
Brand Name:
zichang
Model Number:
302
Application:
Pharmaceutical Intermediates
Appearance:
white powder
Product name:
Pitavastatin 3-Oxo Ethyl Ester
CAS:
148901-69-3
Density:
1.268
Molecular formula:
C27H26FNO4
Molecular Weight:
447.5
Color:
White
Certification:
ISO
Boiling point:
651.3±55.0 °C(Predicted)
Sample:
Availiable
COA:
Availale
Packaging&Delivery
Packaging Details
if order 1-20kg, aluminum foil bag+carton box.
If order is more than 20kg,plastic bag+25kg carton drum
Port
shanghai /qingdao /tianjin
Lead Time:
Quantity(Kilograms) 1 - 500 >500
Est. Time(days) 5 To be negotiated

Property

CAS No.: 148901-69-3 Formula: C27H26FNO4 Molecular Weight: 447.49800

Basic Info

Chemical Name	Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
Synonyms
CAS No.	148901-69-3
Molecular Formula	C27H26FNO4
Molecular Weight	447.49800
PSA	76.49000
LogP	5.20480

Properties

Density	1.268 g/cm3
Boiling Point	651.3ºC at 760 mmHg
Flash Point	347.7ºC
Refractive Index	1.631
Vapor Pressure	7.53E-18mmHg at 25°C

Synthesis Route

Ethyl acetoacetate+(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal→Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol→Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate
2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde→Ethyl (E)-7-[4-(4'-fluorophenyl)-2-(cyclopropyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Precursor

(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol
Ethyl acetoacetate
(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal
2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde

Downstream Product

(E,3S,5R)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid
pitavastatin calcium

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