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(S)-2-AMINO-2-METHYLBUTYRIC ACID

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Origin: China

Cas No: 595-39-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 595-39-1 Formula: C5H11NO2 Molecular Weight: 117.14600

Description

Isovaline is a rare amino acid transported to earth by the Murchison meteorite, which landed in Australia in 1969. The discovery of isovaline in the biosphere demonstrates an extraterrestrial origin of amino acids and has been linked to the homochirality of life on earth suggesting a role in the origin of life.
The structure of isovaline is similar to the amino acids GABA and glycine, the chief inhibitory neurotransmitters in the mammalian central nervous system. Isovaline acts as an analgesic in mice by activating peripheral GABAB receptors. In a mouse model of osteoarthritis isovaline restored mobility, suggesting inhibition of nociception by isovaline in the synovial membrane of the mouse knee.
Isovaline does not cross the blood-brain barrier and does not enter into the brain or spinal cord. Drugs such as opioids cross the blood-brain barrier to produce analgesia but often produce confusion, sedation and addiction.
Isovaline acts downstream to the cyclooxygenase system that NSAIDs inhibit, suggesting a means to avoid adverse effects such as irritation of the gastrointestinal system.
This novel first-in-class compound has potential for treatment of acute and chronic pain, without the negative side effects associated with other commonly used analgesics.

Basic Info

Chemical Name	(S)-2-AMINO-2-METHYLBUTYRIC ACID
Synonyms	CROTYL ALCOHOL; cis/trans-crotyl alcohol; 2-methyl-2-aminobutanoic acid; 2-Butenol; but-2-en-1-ol; DL-Isovaline; 2-amino-2-methylbutanoic acid; MeCHCHCH2OH; 2-Buten-1-o1; L-2-methyl-2-aminobutanoic acid; Crotonyl alcoho1; Z-isovaline; Krotylalkohol; 2-butenylalcohol; 2-BUTENE-1-OL; CH3CH=CHCH2OH;
CAS No.	595-39-1
Molecular Formula	C5H11NO2
Molecular Weight	117.14600
PSA	63.32000
LogP	0.89870

Properties

Density	1.07g/cm3
Boiling Point	213.6ºC at 760mmHg
Flash Point	83ºC

Safety Info

HS Code	2922499990

Synthesis Route

2,4-Imidazolidinedione,5-ethyl-5-methyl-→(S)-2-AMINO-2-METHYLBUTYRIC ACID
potassium cyanide+butan-2-one→(S)-2-AMINO-2-METHYLBUTYRIC ACID
(RS)-2-amino-2-methylbutanamide→(S)-2-AMINO-2-METHYLBUTYRIC ACID

Precursor

potassium cyanide
(RS)-2-amino-2-methylbutanamide
hydrogen cyanide
butan-2-one

Downstream Product

D(-)-Isovaline
2-amino-2-methylbutan-1-ol
L(+)-Isovaline monohydrate
ethyl 2-amino-2-methylbutanoate

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