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(R)-adrenaline

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Origin: China

Cas No: 51-43-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 51-43-4 Formula: C9H13NO3 Molecular Weight: 183.20400

    Description

    Endogenous catcholamine with combined α-and β-agonist activity. Principal sympathomimetic hormone produced by the adrenal medulla. Bronchodilator; cardiostimulant; mydriatic; antiglaucoma.

    Basic Info

    Chemical Name (R)-adrenaline
    Synonyms

    L-Epinephrine;
    1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (R)-;
    Suprel;
    Epifrin;
    IOP;
    Corisol;
    L(-)-Epinephrine;
    (S)-4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol;
    Adrin;
    Adrenan;
    L-Adrenaline;
    Bosmin;
    Adrenal;
    Adrine;
    Exadrin;

    CAS No. 51-43-4
    Molecular Formula C9H13NO3
    Molecular Weight 183.20400
    PSA 72.72000
    LogP 0.74150

    Properties

    Appearance & Physical State white to yellowish fine crystalline powder
    Density 1.283 g/cm3
    Boiling Point 413.1ºC at 760 mmHg
    Melting Point 208-211ºC
    Flash Point 207.9ºC
    Stability Stable. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents. Light sensitive.
    Storage Condition 2-8ºC

    Safety Info

    RTECS DO2625000
    Hazard Class 6.1
    Safety Statements S23-S26-S36/37/39-S45-S61
    HS Code 2922509090
    Packing Group II
    RIDADR UN 2811
    Risk Statements R23/24/25; R33; R36/37/38; R52/53
    Hazard Codes T

    Synthesis Route

    R,S-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-hydroxy-methylamido-ethan→(R)-adrenaline
    2,3-dihydroxybutanedioic acid+adrenaline→(R)-adrenaline
    1-(3,4-dimethoxyphenyl)-2-methylamino-ethanol→(R)-adrenaline

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - man 77 mg/kg 1.Behavioral-hallucinations, distorted perceptions
    2.Behavioral-excitement
    3.Gastrointestinal-nausea or vomiting
    Subcutaneous TDLo - Lowest published toxic dose Human - man 43 ug/kg 1.Cardiac-pulse rate increase, without fall in BP
    2.Gastrointestinal-nausea or vomiting
    3.Skin and Appendages-sweating
    Subcutaneous LDLo - Lowest published lethal dose Human - man 7 ug/kg 1.Brain and Coverings-other degenerative changes
    2.Cardiac-other changes

    Precursor

    1-(3,4-dimethoxyphenyl)-2-methylamino-ethanol
    2,3-dihydroxybutanedioic acid
    R,S-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-hydroxy-methylamido-ethan
    adrenaline

    Downstream Product

    3,4-dihydroxybenzoic acid
    3,4-dimethoxybenzoic acid
    Vanillin
    adrenaline

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