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(R)-noradrenaline

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Origin: China

Cas No: 51-41-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 51-41-2 Formula: C8H11NO3 Molecular Weight: 169.17800

Description

Norepinephrine, also known as noradrenaline, is a medication used to treat people with very low blood pressure. It is manufactured with the same formulation as the hormone and neurotransmitter norepinephrine. It is given intravenously.
At high doses, and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death.

Basic Info

Chemical Name	(R)-noradrenaline
Synonyms	(−)-Norepinephrine; L-Noradrenaline; Norepinephrine; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-;
CAS No.	51-41-2
Molecular Formula	C8H11NO3
Molecular Weight	169.17800
PSA	86.71000
LogP	0.79020

Properties

Appearance & Physical State	crystalline
Density	1.397 g/cm3
Boiling Point	442.6ºC at 760 mmHg
Melting Point	220ºC
Flash Point	221.5ºC
Refractive Index	1.66
Stability	Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20ºC.
Storage Condition	2-8ºC

Safety Info

RTECS	DN5950000
Hazard Class	6.1
Safety Statements	S28-S36/37-S45
HS Code	2922509090
Packing Group	II
WGK Germany	3
RIDADR	UN 2811
Risk Statements	R26/27/28
Hazard Codes	T+

Synthesis Route

Glycine+3,4-dihydroxybenzaldehyde→(R)-noradrenaline+(S)-4-(2-amino-1-hydroxyethyl)pyrocatechol
R,S-2,2'-dinitrobiphenyl-6,6'-dicarbonsaeure-di-N,N'-1-(3,4-dihydroxyphenyl)-1-hydroxy-2-amido-ethan→(R)-noradrenaline
noradrenaline→(R)-noradrenaline

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intravenous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	100 ug/kg	1.Behavioral-somnolence (general depressed activity) 2.Behavioral-muscle weakness 3.Lungs, Thorax, or Respiration-dyspnea
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	20 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	6 mg/kg	1.Details of toxic effects not reported other than lethal dose value