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mianserin

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Origin: China

Cas No: 24219-97-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 24219-97-4 Formula: C18H20N2 Molecular Weight: 264.36500

    Description

    Mianserin (brand names: Depnon (IN), Lantanon (ZA), Lerivon (AR, BE, CZ, PL, RU, SK), Lumin (AU), Norval (UK), Tolvon (AU, HK†, IE†, NZ, SG†), Tolmin (DK); where † indicates discontinued products) is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects.
    It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose.

    Basic Info

    Chemical Name mianserin
    Synonyms

    MIANSERIN;
    Dibenzoc,fpyrazino1,2-aazepine,1,2,3,4,10,14b-hexahydro-2-methyl;
    2-methyl-1,2,3,4,10,14b-hexahydro-dibenzo[c,f]pyrazino[1,2-a]azepine;
    (R)-Mianserine;
    Org-5859;
    Org-4360;
    (S)-Mianserine;
    [3H]-(+/-)-Mianserin;

    CAS No. 24219-97-4
    Molecular Formula C18H20N2
    Molecular Weight 264.36500
    PSA 6.48000
    LogP 3.08680

    Properties

    Density 1.18g/cm3
    Boiling Point 411.3ºC at 760mmHg
    Flash Point 186.1ºC

    Safety Info

    Hazard Class 6.1(b)
    HS Code 2933990090
    Packing Group III
    RIDADR UN 3249

    Synthesis Route

    2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol→mianserin
    →mianserin

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed SE-30 240. 2207. isothermal
    Packed OV-101 - 2208. custom temperature program

    Precursor


    2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol

    Downstream Product

    DESMETHYL MIANSERIN
    Mianserin-d3
    8-Hydroxydesmethylmianserin
    Desmethylmianserin

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