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Gestrinone

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Origin: China

Cas No: 16320-04-0

Specification: 99%min

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 16320-04-0 Formula: C21H24O2 Molecular Weight: 308.41400

    Description

    Gestrinone (INN, USAN, BAN) (brand names Dimetriose, Dimetrose, Nemestran), also known as ethylnorgestrienone (i.e., ethyl derivative of norgestrienone), is a synthetic steroid of the 19-nortestosterone group that is marketed in Europe, Australia, and Latin America, though not the United States, and is used primarily in the treatment of endometriosis. It is a potent mixed progestogen and antiprogestogen (i.e., partial agonist of the progesterone receptor (PR) or selective progesterone receptor modulator (SPRM)), an antigonadotropin, a mild androgen and anabolic steroid, and a functional antiestrogen. Gestrinone is described as similar in action and effect to danazol, which is also used in the treatment of endometriosis, but is reported to have fewer androgenic side effects in comparison. Because of its anabolic effects, the use of gestrinone in competition has been banned by the International Olympic Committee.

    Basic Info

    Chemical Name Gestrinone
    Synonyms

    D-GESTRINONE;
    Dimetriose;
    gestrigone;
    TridoMose;
    Dimetrose;
    NeMestran;

    CAS No. 16320-04-0
    Molecular Formula C21H24O2
    Molecular Weight 308.41400
    PSA 37.30000
    LogP 3.72280

    Properties

    Appearance & Physical State Light yellow solid
    Density 1.18g/cm3
    Boiling Point 507.6ºC at 760mmHg
    Melting Point 154ºC
    Flash Point 214.9ºC
    Refractive Index 1.607

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LDLo - Lowest published lethal dose Rodent - rat 1 gm/kg 1.Behavioral-altered sleep time (including change in righting reflex)
    2.Skin and Appendages-dermatitis, other (after systemic exposure)
    3.Nutritional and Gross Metabolic-other changes
    Intraperitoneal LDLo - Lowest published lethal dose Rodent - rat 1 gm/kg 1.Sense Organs and Special Senses (Eye)-visual field changes
    2.Behavioral-altered sleep time (including change in righting reflex)
    3.Nutritional and Gross Metabolic-other changes
    Intraperitoneal LDLo - Lowest published lethal dose Rodent - mouse 1 gm/kg 1.Behavioral-altered sleep time (including change in righting reflex)
    2.Behavioral-convulsions or effect on seizure threshold
    3.Gastrointestinal-other changes

    Downstream Product

    (8S,13S,14S,17S)-13,17-diethyl-17-hydroxy-1,2,6,7,8,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

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