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dydrogesterone

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Origin: China

Cas No: 152-62-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    152-62-5
    Other Names:
    Dydrogesterone
    MF:
    C21H28O2, C21H28O2
    EINECS No.:
    205-806-8
    Place of Origin:
    Shaanxi, China
    Type:
    Vitamins, Amino Acids and Coenzymes
    Grade Standard:
    Cosmetic Grade, Food Grade, Medicine Grade, Food Grade, Medicine Grade
    Usage:
    Animal Pharmaceuticals
    Brand Name:
    Chance, Chance
    Model Number:
    Chance-831612
    Purity:
    99%min
    Product Name:
    Dydrogesterone
    CAS:
    152-62-5
    EINECS:
    205-806-8
    Appearance:
    White Powder
    Certificate:
    ISO 9001
    Storage:
    Dry Place
    MOQ:
    1kg

    Packaging&Delivery

    Packaging Details
    1kg with double plastic bag inside,foil bag outside
    25kg with double plastic bag inside,fiber drum outside
    Port
    any port in China
  • Property

    CAS No.: 152-62-5 Formula: C21H28O2 Molecular Weight: 312.44600

    Description

    Dydrogesterone (INN, USAN, BAN), also known as isopregnenone or 6-dehydroretroprogesterone, as well as 9β,10α-pregna-4,6-diene-3,20-dione, is a steroidal, pure progestin that was developed in the 1950s.
    Dydrogesterone has selective progestational activity and does not inhibit ovulation. The greater rigidity of dydrogesterone also positively affects its selectivity, while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10–20 times lower than that of oral micronized progesterone.
    Dydrogesterone is used as an effective, orally active progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. The molecular structure and pharmacological effects are somewhat similar to endogenous progesterone, although in smaller amounts it is found to be orally active. Its freedom from hormonal effects like those related to corticoid, androgenic, estrogenic, anabolic, and other effects gives dydrogesterone an advantage over other synthesized progestogens.
    Dydrogesterone when used therapeutically is closely related to its physiological action on the neuro-endocrine control of ovarian function, as well as on the endometrium. This is an indication in all cases of endogeneous progesterone deficiency - relative or absolute. The molecule was licensed for use in several indications, including threatened or recurrent miscarriage, dysfunctional bleeding, infertility due to luteal insufficiency, dysmenorrhea, endometriosis, secondary amenorrhoea, irregular cycles, pre-menstrual syndrome and also as a hormone replacement therapy. Dydrogesterone has proven effective in the following conditions associated with progesterone deficiency:
    Infertility due to luteal insufficiency Threatened miscarriage Habitual or recurrent miscarriage. Menstrual disorders Premenstrual syndrome Endometriosis
    Dydrogesterone has also been registered as hormone replacement therapy (HRT) to counter-check the negative effects of unopposed estrogen on the endometrium in women with an intact uterus. Dydrogesterone is relatively safe and well tolerated, and does not exhibit the androgenic side effects that are common with some other progestins, like medroxyprogesterone acetate.

    Basic Info

    Chemical Name dydrogesterone
    Synonyms

    Dydrogesterone;
    (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one;

    CAS No. 152-62-5
    Molecular Formula C21H28O2
    Molecular Weight 312.44600
    PSA 34.14000
    LogP 4.49950

    Properties

    Density 1.1g/cm3
    Boiling Point 462.8ºC at 760mmHg
    Melting Point 168-173ºC
    Flash Point 172.2ºC
    Refractive Index 1.556
    Vapor Pressure 9.55E-09mmHg at 25°C

    Safety Info

    WGK Germany 3

    Synthesis Route

    3.20-Dioxo-pregnadien-(4.7)dydrogesterone

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >4600 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse >7200 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Subcutaneous TDLo - Lowest published toxic dose Rodent - rat 70 mg/kg,female 14 day(s) pre-mating 1.Reproductive-Maternal Effects-ovaries, fallopian tubes
    2.Reproductive-Fertility-other measures of fertility

    Precursor

    3.20-Dioxo-pregnadien-(4.7)

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