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ethisterone

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Origin: China

Cas No: 434-03-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
434-03-7
Other Names:
4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
MF:
C21H28O2
EINECS No.:
207-096-5
Place of Origin:
Jiangsu, China
Type:
Endocrine System Agents, Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
KPRX
Model Number:
CAS 434-03-7
Purity:
99%
Product name:
Estrogen Powder CAS 434-03-7
Appearance:
White powder
Application:
Pharmaceuticals intermediate
Name:
Ethisterone
Description:
Synthetic progestogen
Uses:
intermediate in the synthesis of Spironolactone
Keyword:
Steroid and Hormone;progestogen estrogen
Packaging&Delivery
Packaging Details
20kg/drum
Pallet can be avialable for bulk order.
Port
shanghai or ningbo
Lead Time:
Quantity(Kilograms) 1 - 100 >100
Est. Time(days) 3 To be negotiated

Property

CAS No.: 434-03-7 Formula: C21H28O2 Molecular Weight: 312.44600

Description

Ethisterone (INN, USAN, BAN) (brand names Pranone, Progestoral, Lutocylol, Proluton C, many others), also known as 17α-ethinyltestosterone, pregneninolone, and anhydrohydroxyprogesterone, is a steroidal progestin drug and was the first progestin, as well as the first orally active progestogen (it followed injected progesterone (Proluton), which was marketed in 1934), to be introduced.
It was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin, derived from testosterone, and was marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone. Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel (Ciba, Organon, Roussel).; Ethisterone is described as a relatively weak progestogen, similarly to its analogue dimethisterone. It has strong androgenic effects, and this has limited its use. Because of its potent androgenic activity, ethisterone has been associated with the masculinization of female fetuses in women who have taken it during pregnancy.

Basic Info

Chemical Name	ethisterone
Synonyms	Produxan; Ethisterone; Gestoral; Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17α)-; Colutoid; Ethinone; Pregnin; Prone; 17β-Hydroxy-4,17α-pregnen-20-yn-3-one; Prodoxan; Pranone; 4,17α-Pregnen-17β-ol-20-yn-3-one; Prolutol;
CAS No.	434-03-7
Molecular Formula	C21H28O2
Molecular Weight	312.44600
PSA	37.30000
LogP	3.88260

Properties

Appearance & Physical State	Off-white powder
Density	1.13g/cm3
Boiling Point	446.4ºC at 760mmHg
Melting Point	266-273ºC
Flash Point	190.2ºC
Stability	Stable at normal temperatures and pressures.
Storage Condition	Keep tightly closed. Store in a cool dry place.
Vapor Pressure	7.59E-10mmHg at 25°C

Safety Info

Hazard Class	6.1
Safety Statements	S22-S24/25
HS Code	2942000000
RIDADR	UN 2811
Risk Statements	R40; R48
Hazard Codes	Xn

Synthesis Route

21-bromo-17α-hydroxy-4-pregnene-3,20-dione→ethisterone+REICHSTEIN'S SUBSTANCE S 21-ACETATE
androst-4-ene-3,17-dione+acetylene→ethisterone
17.α.-Pregn-5-en-20-yne-3.β.,17.β.-diol→ethisterone

Precursor

acetylene
21-bromo-17α-hydroxy-4-pregnene-3,20-dione
androst-4-ene-3,17-dione
17.α.-Pregn-5-en-20-yne-3.β.,17.β.-diol

Downstream Product

(8R,9S,10R)-10,17,17-trimethyl-1,2,6,7,8,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one
16,17-didehydroprogesterone
REICHSTEIN'S SUBSTANCE S 21-ACETATE
17Alpha-Hydroxyprogesterone

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