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ethisterone

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Origin: China

Cas No: 434-03-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    434-03-7
    Other Names:
    4,17ALPHA-PREGNEN-17BETA-OL-20-YN-3-ONE
    MF:
    C21H28O2
    EINECS No.:
    207-096-5
    Place of Origin:
    Jiangsu, China
    Type:
    Endocrine System Agents, Auxiliaries and Other Medicinal Chemicals
    Grade Standard:
    Medicine Grade
    Brand Name:
    KPRX
    Model Number:
    CAS 434-03-7
    Purity:
    99%
    Product name:
    Estrogen Powder CAS 434-03-7
    Appearance:
    White powder
    Application:
    Pharmaceuticals intermediate
    Name:
    Ethisterone
    Description:
    Synthetic progestogen
    Uses:
    intermediate in the synthesis of Spironolactone
    Keyword:
    Steroid and Hormone;progestogen estrogen

    Packaging&Delivery

    Packaging Details
    20kg/drum
    Pallet can be avialable for bulk order.
    Port
    shanghai or ningbo
    Lead Time:
    Quantity(Kilograms)1 - 100>100
    Est. Time(days)3To be negotiated
  • Property

    CAS No.: 434-03-7 Formula: C21H28O2 Molecular Weight: 312.44600

    Description

    Ethisterone (INN, USAN, BAN) (brand names Pranone, Progestoral, Lutocylol, Proluton C, many others), also known as 17α-ethinyltestosterone, pregneninolone, and anhydrohydroxyprogesterone, is a steroidal progestin drug and was the first progestin, as well as the first orally active progestogen (it followed injected progesterone (Proluton), which was marketed in 1934), to be introduced.
    It was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin, derived from testosterone, and was marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone. Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel (Ciba, Organon, Roussel).; Ethisterone is described as a relatively weak progestogen, similarly to its analogue dimethisterone. It has strong androgenic effects, and this has limited its use. Because of its potent androgenic activity, ethisterone has been associated with the masculinization of female fetuses in women who have taken it during pregnancy.

    Basic Info

    Chemical Name ethisterone
    Synonyms

    Produxan;
    Ethisterone;
    Gestoral;
    Pregn-4-en-20-yn-3-one, 17-hydroxy-, (17α)-;
    Colutoid;
    Ethinone;
    Pregnin;
    Prone;
    17β-Hydroxy-4,17α-pregnen-20-yn-3-one;
    Prodoxan;
    Pranone;
    4,17α-Pregnen-17β-ol-20-yn-3-one;
    Prolutol;

    CAS No. 434-03-7
    Molecular Formula C21H28O2
    Molecular Weight 312.44600
    PSA 37.30000
    LogP 3.88260

    Properties

    Appearance & Physical State Off-white powder
    Density 1.13g/cm3
    Boiling Point 446.4ºC at 760mmHg
    Melting Point 266-273ºC
    Flash Point 190.2ºC
    Stability Stable at normal temperatures and pressures.
    Storage Condition Keep tightly closed. Store in a cool dry place.
    Vapor Pressure 7.59E-10mmHg at 25°C

    Safety Info

    Hazard Class 6.1
    Safety Statements S22-S24/25
    HS Code 2942000000
    RIDADR UN 2811
    Risk Statements R40; R48
    Hazard Codes Xn

    Synthesis Route

    21-bromo-17α-hydroxy-4-pregnene-3,20-dioneethisterone+REICHSTEIN'S SUBSTANCE S 21-ACETATE
    androst-4-ene-3,17-dione+acetyleneethisterone
    17.α.-Pregn-5-en-20-yne-3.β.,17.β.-diolethisterone

    Precursor

    acetylene
    21-bromo-17α-hydroxy-4-pregnene-3,20-dione
    androst-4-ene-3,17-dione
    17.α.-Pregn-5-en-20-yne-3.β.,17.β.-diol

    Downstream Product

    (8R,9S,10R)-10,17,17-trimethyl-1,2,6,7,8,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-3-one
    16,17-didehydroprogesterone
    REICHSTEIN'S SUBSTANCE S 21-ACETATE
    17Alpha-Hydroxyprogesterone

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