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Ezetimibe

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Origin: China

Cas No: 163222-33-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
163222-33-1
Other Names:
Ezetimibe
MF:
C24H21F2NO3, C24H21F2NO3
EINECS No.:
N/A
Place of Origin:
Shandong, China
Type:
Pharmaceutical Intermediates
Purity:
99.0%min
Brand Name:
ench- 99% Ezetimibe / 163222-33-1
Model Number:
99%min
Application:
Pharm Intermediates
Appearance:
White Powder
MW::
409.43
Color:
White Powder
Product name:
Ezetimibe
CAS:
163222-33-1
Melting point:
164-166°C
storage temp.:
Refrigerator
water:
0.5%
Usage:
Pharm Intermediates
Packaging&Delivery
Packaging Details
1-1000g/bags ,25kg/drums-- professional manufacture 163222-33-1
Port
any port in china

Property

CAS No.: 163222-33-1 Formula: C24H21F2NO3 Molecular Weight: 409.42500

Description

Ezetimibe is a drug that lowers plasma cholesterol levels. It acts by decreasing cholesterol absorption in the small intestine. It may be used alone (marketed as Zetia or Ezetrol), when other cholesterol-lowering medications are not tolerated, or together with statins (e.g., ezetimibe/simvastatin, marketed as Vytorin and Inegy) when statins alone do not control cholesterol.
Ezetimibe is recommended as second line therapy for those intolerant of statins or unable to achieve target LDL cholesterol levels on statins alone by several major medical group practice guidelines, but not by those of the American Heart Association and American College of Cardiology. In the United States as of 2015 the 10 mg pill costs between 4.84 and 7.88 USD.

Basic Info

Chemical Name	Ezetimibe
Synonyms	(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; Ezetrol; Zetia; Ezetimib; [Ezetimide];
CAS No.	163222-33-1
Molecular Formula	C24H21F2NO3
Molecular Weight	409.42500
PSA	60.77000
LogP	4.95330

Properties

Melting Point	164-166°C

Safety Info

Safety Statements	S26; S36
HS Code	2934999090
Risk Statements	R36/37/38

Synthesis Route

(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one→Ezetimibe
4'-O-Benzyloxy Ezetimibe→Ezetimibe
benzyl (4-((1S,2R,5S)-5-(4-fluorophenyl)-1-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidine-3-carbonyl)-5-((trimethylsilyl)oxy)pentyl)phenyl) carbonate→Ezetimibe

Precursor

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-phenylmethoxyphenyl)azetidin-2-one
benzyl (4-((1S,2R,5S)-5-(4-fluorophenyl)-1-((4-fluorophenyl)amino)-2-((S)-2-oxo-4-phenyloxazolidine-3-carbonyl)-5-((trimethylsilyl)oxy)pentyl)phenyl) carbonate
(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one
4'-O-Benzyloxy Ezetimibe

Downstream Product

Ezetimibe Diacetate

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