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Ezetimibe Diacetate

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Origin: China

Cas No: 163380-20-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 163380-20-9 Formula: C28H25F2NO5 Molecular Weight: 493.49900

Description

Protected Ezetimibe derivative.

Basic Info

Chemical Name	Ezetimibe Diacetate
Synonyms	[4-[(2S,3R)-3-[(3R)-3-acetyloxy-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenyl] acetate;
CAS No.	163380-20-9
Molecular Formula	C28H25F2NO5
Molecular Weight	493.49900
PSA	72.91000
LogP	5.74380

Synthesis Route

Acetic anhydride+Ezetimibe→Ezetimibe Diacetate
→Ezetimibe Diacetate
3-[(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-phenylmethoxyphenyl)azetidin-3-yl]propanoic acid→Ezetimibe Diacetate

Precursor

Ezetimibe
Acetic anhydride
3-[(3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-phenylmethoxyphenyl)azetidin-3-yl]propanoic acid
3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl)azetidin-3-yl)propionic acid chloride

Downstream Product

[1-(4-fluorophenyl)-3-[1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxoazetidin-3-yl]propyl] acetate

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