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4'-O-Benzyloxy Ezetimibe

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Origin: China

Cas No: 163222-32-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 163222-32-0 Formula: C31H27F2NO3 Molecular Weight: 499.54800

Description

Protected Ezetimibe, used for the synthesis of related derivatives.

Basic Info

Chemical Name	4'-O-Benzyloxy Ezetimibe
Synonyms	2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)-;
CAS No.	163222-32-0
Molecular Formula	C31H27F2NO3
Molecular Weight	499.54800
PSA	49.77000
LogP	6.82670

Properties

Appearance & Physical State	Off-white solid
Density	1.27g/cm3
Boiling Point	706.462ºC at 760 mmHg
Refractive Index	1.617
Vapor Pressure	0mmHg at 25°C

Synthesis Route

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-phenylmethoxyphenyl)azetidin-2-one→4'-O-Benzyloxy Ezetimibe
+4-Fluorophenylmagnesium bromide→4'-O-Benzyloxy Ezetimibe
1 -(4-fluorophenyl)-4(S)-(4-hydroxyphenyl)-3(R)-(3-oxo-3-phenylpropyl)-2-azetidinone→4'-O-Benzyloxy Ezetimibe

Precursor

(3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-phenylmethoxyphenyl)azetidin-2-one
4-Fluorophenylmagnesium bromide
(3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one

Downstream Product

Ezetimibe
Ezetimibe Diacetate
2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide

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