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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Respiratory system> acrivastine
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acrivastine

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Origin: China

Cas No: 87848-99-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 87848-99-5 Formula: C22H24N2O2 Molecular Weight: 348.43800

    Description

    Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors.
    This non-sedating[verification needed] antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK. It is available as an over-the-counter medicine in the UK, and is available with or without pseudoephedrine under the Benadryl brand.
    In the U.S., acrivastine is the active ingredient in the Semprex brand. Semprex-D also contains the decongestant pseudoephedrine. Semprex-D is marketed in the U.S. by Actient Pharmaceuticals.

    Basic Info

    Chemical Name acrivastine
    Synonyms

    Semprex;
    Acrivastin;
    Acrivastinum;
    BW A825C;
    Acrivastina;
    (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-yl]prop-2-enoic acid;
    ACRIVASTINE;
    BW 825C;

    CAS No. 87848-99-5
    Molecular Formula C22H24N2O2
    Molecular Weight 348.43800
    PSA 53.43000
    LogP 3.95320

    Properties

    Density 1.17 g/cm3
    Boiling Point 555.1ºC at 760 mmHg
    Melting Point 55.5-59.5 °C(lit.)
    Flash Point 289.5ºC
    Refractive Index 1.627
    Stability Stable at normal temperatures and pressures.
    Storage Condition No storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

    Safety Info

    Safety Statements S37/39
    WGK Germany 3
    Risk Statements R22; R43
    Hazard Codes Xn; Xi

    Synthesis Route

    2,6-Dibromopyridine→acrivastine
    (6-bromopyridin-2-yl)-(2-methylphenyl)methanone→acrivastine
    2-bromo-6-[2-(4-methylphenyl)-1,3-dioxolan-2-yl]pyridine→acrivastine

    Precursor

    2,6-Dibromopyridine
    6-(2-(p-tolyl)-1,3-dioxolan-2-yl)picolinaldehyde
    2-bromo-6-[2-(4-methylphenyl)-1,3-dioxolan-2-yl]pyridine
    (6-bromopyridin-2-yl)-(2-methylphenyl)methanone

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