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(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

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Origin: China

Cas No: 83647-97-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 83647-97-6 Formula: C22H30N2O5S2 Molecular Weight: 466.61400

Basic Info

Chemical Name	(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
Synonyms	Setrilan; Spiraprilum [Latin]; Espirapril [Spanish]; Sandopril; Spirapril; Renormax; Not established; Spirapril (INN); Spirapril [INN:BAN];
CAS No.	83647-97-6
Molecular Formula	C22H30N2O5S2
Molecular Weight	466.61400
PSA	146.54000
LogP	2.71960

Properties

Density	1.32 g/cm3
Boiling Point	697.8ºC at 760 mmHg
Flash Point	375.8ºC
Refractive Index	1.621

Synthesis Route

N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine→(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
N-Cbz-4-keto-L-proline ethyl ester→(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
N-[(phenylmethoxy)carbonyl]-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid ethyl ester→(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid

Precursor

N-Carbobenzyloxy-4-keto-L-proline
N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine
N-[(phenylmethoxy)carbonyl]-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid ethyl ester
5,5-dimethyl-2-methylsulfanyl-4,5-dihydro-oxazole-4-carboxylic acid ethyl ester

Downstream Product

(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid,hydrochloride

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