Início > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

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Origem: China

Cas No: 87679-37-6

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 50 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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Especificação de produtos
Descrição do produto

Property

CAS No.: 87679-37-6 Formula: C24H34N2O5 Molecular Weight: 430.53700

Description

An antihypertensive. Angiotensin converting enzyme (ACE) inhibitor.

Basic Info

Chemical Name	(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Synonyms	Trandolaprilum [Latin]; Preran; Trandolaprilum; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid,form I crystalline polymorph of; Trandolapril; Gopten; Mavik; 1-[2-[(1-ethoxycarbonyl-3-phenylpropyl)amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; Odrik; Udrik; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid; (3aR,7aS)-1-[N-1(S)-(ethoxycarbonyl)-3-phenylpropyl]-(S)-alanyl-octahydro-1H-indole-2(S)-carboxylic acid; Odric; (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid,form II crystalline polymorph of;
CAS No.	87679-37-6
Molecular Formula	C24H34N2O5
Molecular Weight	430.53700
PSA	95.94000
LogP	3.10210

Properties

Appearance & Physical State	White powder
Density	1.181 g/cm3
Boiling Point	626ºC at 760 mmHg
Melting Point	122-123ºC
Flash Point	332.4ºC
Refractive Index	1.549
Storage Condition	Room temp

Safety Info

RTECS	NL6015178

Synthesis Route

benzyl 2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylate+N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine→(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
benzyl 2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylate+N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine→N-[1-(S)-carbethoxy-3-phenylpropyl]-(S)-alanyl-2R,3aS,7aR-octahydroindole-2-carboxylic acid+(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
trandolapril benzyl ester→(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

Precursor

N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine
N-[(S)-1-carbethoxy-3-phenyl-propyl]-S-alaninoyl chloride hydrochloride
benzyl 2,3,3a,4,5,6,7,7a-octahydro-1H-indole-2-carboxylate
trandolapril benzyl ester

Downstream Product

N-[(S)-(+)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanine

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