Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

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Origin: China

Cas No: 82419-35-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
82419-35-0
Other Names:
Oxygen-fluorine
MF:
C13H9F2NO4
EINECS No.:
82419-35-0
Place of Origin:
China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Food Grade, Medicine Grade
Brand Name:
Sincere-Chem
Model Number:
Sincere-Chem 82419-35-0
Purity:
99%
Melting point:
320-322 °C(lit.)
Boiling point:
459.2±45.0 °C(Predicted)
density:
1.61±0.1 g/cm3(Predicted)
storage temp.:
-20°C Freezer
pka:
4.87±0.40(Predicted)
Product Name:
Oxygen-fluorine acid
MW:
281.21
Samples:
Available
COA:
Avaialble
Quality:
High quality
Packaging&Delivery
Packaging Details
1kg/ Aluminum Foil Bag with one plastic-bags inside;
5 kg/Aluminum Foil Bag with one plastic-bags inside;
25 kg/drum or as customer's requirement
Port
Qingdao Port, China; Shanghai port, China
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 2 To be negotiated

Property

CAS No.: 82419-35-0 Formula: C13H9F2NO4 Molecular Weight: 281.21200

Description

Ofloxacin intermediate.

Basic Info

Chemical Name	9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
Synonyms	82419-35-0;
CAS No.	82419-35-0
Molecular Formula	C13H9F2NO4
Molecular Weight	281.21200
PSA	68.53000
LogP	1.93130

Properties

Appearance & Physical State	grey-yellow powder
Density	1.61 g/cm3
Boiling Point	459.2ºC at 760 mmHg
Melting Point	320-322ºC(lit.)
Flash Point	231.5ºC
Storage Condition	-20ºC Freezer

Safety Info

Safety Statements	S26-S36
HS Code	2934999090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi
Symbol	GHS07
Hazard Declaration	H315; H319; H335
Caution Statement	P261; P305 + P351 + P338
Signal Word	Warning

Synthesis Route

Ethyl 2-(2-nitro-3,4,5-trifluoro)benzoyl-3-[(1-t-butyldimethylsilyloxyprop-2-yl)amino]acrylate+tetrabutylammonium fluoride→9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate→9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate→9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Precursor

6-amino-2,3-difluorophenol
Ethyl 2-(2-nitro-3,4,5-trifluoro)benzoyl-3-[(1-t-butyldimethylsilyloxyprop-2-yl)amino]acrylate
ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate
diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate

Downstream Product

ofloxacin
4-n-Propyl ofloxacin
N-Demethylofloxacin
124338-73-4

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