Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Cardiovascular system> (4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid

(4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid

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Origin: China

Cas No: 167305-00-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 167305-00-2 Formula: C19H24N2O4S2 Molecular Weight: 408.53500

Description

Omapatrilat (INN) is a novel antihypertensive agent that inhibits both neutral endopeptidase (NEP) and angiotensin converting enzyme. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.
This drug from Bristol-Myers Squibb was not approved by the U.S. Food and Drug Administration due to angioedema safety concerns.
Omapatrilat angioedema was attributed to its dual mechanism of action, inhibiting both angiotensin converting enzyme (ACE), and neutral endopeptidase, both of these enzymes are responsible for the metabolism of bradykinin which causes vasodilation, angioedema, and airway obstruction.

Basic Info

Chemical Name	(4S,7S,10aS)-5-oxo-4-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3,4,7,8,9,10,10a-octahydropyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
Synonyms	Omapatrilat; Omapatrilat (JAN/USAN/INN);
CAS No.	167305-00-2
Molecular Formula	C19H24N2O4S2
Molecular Weight	408.53500
PSA	150.81000
LogP	2.26980

Properties

Density	1.37g/cm3
Boiling Point	724.2ºC at 760mmHg
Flash Point	391.8ºC
Refractive Index	1.645
Vapor Pressure	5.17E-22mmHg at 25°C

Safety Info

Hazard Declaration	H315; H319; H335
Caution Statement	P305 + P351 + P338
Symbol	GHS07
Signal Word	Warning

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