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4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide

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Origin: China

Cas No: 84088-42-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 84088-42-6 Formula: C18H16N2O3 Molecular Weight: 308.33100

Description

Roquinimex (Linomide) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity. It also inhibits angiogenesis and reduces the secretion of TNF alpha.
Roquinimex has been investigated as a treatment for some cancers (including as adjuvant therapy after bone marrow transplantation in acute leukemia) and autoimmune diseases, such as multiple sclerosis and recent-onset type I diabetes. Several trials have been terminated due to serious cardiovascular toxicity.

Basic Info

Chemical Name	4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide
Synonyms	LS-2616; FCF-89; Linomide; ROQUINIMEX; N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide;
CAS No.	84088-42-6
Molecular Formula	C18H16N2O3
Molecular Weight	308.33100
PSA	62.54000
LogP	2.52070

Properties

Density	1.357g/cm3
Boiling Point	436.187ºC at 760 mmHg
Flash Point	217.598ºC
Refractive Index	1.686
Storage Condition	2-8ºC

Safety Info

Safety Statements	S36/37
HS Code	2933790090
RIDADR	UN 2811
Risk Statements	R22
Hazard Codes	Xn

Synthesis Route

4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylic acid+N-methylaniline→4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide
N-methylisatoic anhydride+methyl 3-(N-methyl-N-phenylamino)-3-oxopropanoate→4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide
ethyl 4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate+N-methylaniline→4-hydroxy-N,1-dimethyl-2-oxo-N-phenylquinoline-3-carboxamide

Precursor

ethyl 4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylate
4-hydroxy-1-methyl-2-oxoquinoline-3-carboxylic acid
N-methylaniline
N-methylisatoic anhydride

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