Home > Chiral Compounds> (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one

(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one

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Origin: China

Cas No: 132127-34-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 132127-34-5 Formula: C9H9NO2 Molecular Weight: 163.17300

Description

Docetaxel or Paclitaxel intermediate.

Basic Info

Chemical Name	(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one
Synonyms	(3R,4S)-3-hydroxy-4-phenylazetidin-2-one;
CAS No.	132127-34-5
Molecular Formula	C9H9NO2
Molecular Weight	163.17300
PSA	49.33000
LogP	0.54720

Properties

Appearance & Physical State	white solid
Density	1.308
Boiling Point	430.414ºC at 760 mmHg
Melting Point	187-188ºC
Refractive Index	1.612
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2933790090

Synthesis Route

2-Azetidinone, 4-phenyl-3-(phenylmethoxy)-, (3R-cis)-→(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one
2-Azetidinone, 4-phenyl-3-[(trimethylsilyl)oxy]-, (3R,4S)-→(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one
(3R,4S)-3-triisopropylsilyloxy-4-phenylazetidin-2-one→(3R,4S)-3-Hydroxy-4-phenylazetidin-2-one

Precursor

[(3R,4S)-2-oxo-4-phenylazetidin-3-yl] acetate
2-Azetidinone, 4-phenyl-3-(phenylmethoxy)-, (3R-cis)-
(3R,4S)-3-triisopropylsilyloxy-4-phenylazetidin-2-one
2-Azetidinone, 4-phenyl-3-[(trimethylsilyl)oxy]-, (3R,4S)-

Downstream Product

(2R,3S)-3-Phenylisoserine
(2R,3S)-3-Phenylisoserine hydrochloride
(3R,4S)-1-Benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone
3-(1-ethoxyethoxy)-4-phenylazetidin-2-one

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