Welcome to GlobalChemMall

ALL CATEGORIES
Categories
Picture of (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 208110-64-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

  • Products Specification
  • Product Description
  • Property

    CAS No.: 208110-64-9 Formula: C20H22ClF2N3O Molecular Weight: 393.85800

    Description

    Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).
    Befiradol was discovered and developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, befiradol was out-licensed to Neurolixis, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose befiradol for the treatment of Levodopa-induced dyskinesia in Parkinson's disease. In support of this indication, preclinical data was published describing the activity of befiradol in animal models of Parkinson's disease.

    Basic Info

    Chemical Name (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
    Synonyms

    UNII-RAT9OHA1YH;
    Befiradol;

    CAS No. 208110-64-9
    Molecular Formula C20H22ClF2N3O
    Molecular Weight 393.85800
    PSA 45.23000
    LogP 4.24540

    Properties

    Density 1.3

    Synthesis Route

    [1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl](cyano)methanol+(5-Methylpyridin-2-yl)methanamine(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
    1,4-Dioxa-8-azaspiro[4.5]decane(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone
    3-Chloro-4-fluorobenzoyl chloride(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone

    Precursor

    3-Chloro-4-fluorobenzoyl chloride
    1-(3-Chloro-4-fluorobenzoyl)-4-piperidinone
    (5-Methylpyridin-2-yl)methanamine
    [1-(3-chloro-4-fluorobenzoyl)-4-fluoropiperidin-4-yl](cyano)methanol

Hot tags: (3-chloro-4-fluorophenyl)-[4-fluoro-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone, China, manufacturers, suppliers, factory, wholesale, low price, high quality